Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding

Hedonic feeding occurs in the absence of metabolic need and plays a critical role in the excessive feeding that underlies obesity. The authors show that optogenetic manipulation of NAc inputs from the prefrontal cortex versus inputs from the anterior paraventricular nucleus of the thalamus has oppos...

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Autores principales:	Daniel J. Christoffel, Jessica J. Walsh, Boris D. Heifets, Paul Hoerbelt, Sophie Neuner, Gordon Sun, Vinod K. Ravikumar, Hemmings Wu, Casey H. Halpern, Robert C. Malenka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc4c39bb7f6944bfa8bad98eab1b23eb
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spelling	oai:doaj.org-article:cc4c39bb7f6944bfa8bad98eab1b23eb2021-12-02T14:17:29ZInput-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding10.1038/s41467-021-22430-72041-1723https://doaj.org/article/cc4c39bb7f6944bfa8bad98eab1b23eb2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22430-7https://doaj.org/toc/2041-1723Hedonic feeding occurs in the absence of metabolic need and plays a critical role in the excessive feeding that underlies obesity. The authors show that optogenetic manipulation of NAc inputs from the prefrontal cortex versus inputs from the anterior paraventricular nucleus of the thalamus has opposite effects on high fat intake.Daniel J. ChristoffelJessica J. WalshBoris D. HeifetsPaul HoerbeltSophie NeunerGordon SunVinod K. RavikumarHemmings WuCasey H. HalpernRobert C. MalenkaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel J. Christoffel Jessica J. Walsh Boris D. Heifets Paul Hoerbelt Sophie Neuner Gordon Sun Vinod K. Ravikumar Hemmings Wu Casey H. Halpern Robert C. Malenka Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
description	Hedonic feeding occurs in the absence of metabolic need and plays a critical role in the excessive feeding that underlies obesity. The authors show that optogenetic manipulation of NAc inputs from the prefrontal cortex versus inputs from the anterior paraventricular nucleus of the thalamus has opposite effects on high fat intake.
format	article
author	Daniel J. Christoffel Jessica J. Walsh Boris D. Heifets Paul Hoerbelt Sophie Neuner Gordon Sun Vinod K. Ravikumar Hemmings Wu Casey H. Halpern Robert C. Malenka
author_facet	Daniel J. Christoffel Jessica J. Walsh Boris D. Heifets Paul Hoerbelt Sophie Neuner Gordon Sun Vinod K. Ravikumar Hemmings Wu Casey H. Halpern Robert C. Malenka
author_sort	Daniel J. Christoffel
title	Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
title_short	Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
title_full	Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
title_fullStr	Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
title_full_unstemmed	Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
title_sort	input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc4c39bb7f6944bfa8bad98eab1b23eb
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Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding

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