Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature

Pleural effusions are rarely observed in association with acute myeloid leukemia (AML), and their true incidence remains unknown. Given the low diagnostic yield from cytopathologic analysis of malignant pleural effusions and the fact that patients with leukemia are often thrombocytopenic and unable...

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Autores principales:	Wang Sing-Ting, Chen Chieh-Lung, Liang Shih-Hsin, Yeh Shih-Peng, Cheng Wen-Chien
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	acute myeloid leukemia leukemic pleural effusion adenosine deaminase extramedullary Medicine R
Acceso en línea:	https://doaj.org/article/cc4d1df278e2429aa432d82c2c2bec43
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spelling	oai:doaj.org-article:cc4d1df278e2429aa432d82c2c2bec432021-12-05T14:10:54ZAcute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature2391-546310.1515/med-2021-0243https://doaj.org/article/cc4d1df278e2429aa432d82c2c2bec432021-03-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0243https://doaj.org/toc/2391-5463Pleural effusions are rarely observed in association with acute myeloid leukemia (AML), and their true incidence remains unknown. Given the low diagnostic yield from cytopathologic analysis of malignant pleural effusions and the fact that patients with leukemia are often thrombocytopenic and unable to tolerate invasive procedures, the incidence of leukemic effusions may be underestimated. Here, we report a rare case of pleural effusion in a patient with newly diagnosed AML. Initial analysis revealed an exudative, lymphocyte-predominant effusion. High levels of adenosine deaminase (ADA) were detected in pleural fluid, consistent with a diagnosis of tuberculosis. However, the analysis of pleural cytology revealed leukemic cells, permitting the diagnosis of leukemic effusion to be made. The patient underwent induction chemotherapy and pleural effusion resolved without recurrence. This case emphasizes the diagnostic dilemma presented by high levels of ADA in a leukemic pleural effusion, as this association has not been previously considered in the literature.Wang Sing-TingChen Chieh-LungLiang Shih-HsinYeh Shih-PengCheng Wen-ChienDe Gruyterarticleacute myeloid leukemialeukemic pleural effusionadenosine deaminaseextramedullaryMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 387-396 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute myeloid leukemia leukemic pleural effusion adenosine deaminase extramedullary Medicine R
spellingShingle	acute myeloid leukemia leukemic pleural effusion adenosine deaminase extramedullary Medicine R Wang Sing-Ting Chen Chieh-Lung Liang Shih-Hsin Yeh Shih-Peng Cheng Wen-Chien Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature
description	Pleural effusions are rarely observed in association with acute myeloid leukemia (AML), and their true incidence remains unknown. Given the low diagnostic yield from cytopathologic analysis of malignant pleural effusions and the fact that patients with leukemia are often thrombocytopenic and unable to tolerate invasive procedures, the incidence of leukemic effusions may be underestimated. Here, we report a rare case of pleural effusion in a patient with newly diagnosed AML. Initial analysis revealed an exudative, lymphocyte-predominant effusion. High levels of adenosine deaminase (ADA) were detected in pleural fluid, consistent with a diagnosis of tuberculosis. However, the analysis of pleural cytology revealed leukemic cells, permitting the diagnosis of leukemic effusion to be made. The patient underwent induction chemotherapy and pleural effusion resolved without recurrence. This case emphasizes the diagnostic dilemma presented by high levels of ADA in a leukemic pleural effusion, as this association has not been previously considered in the literature.
format	article
author	Wang Sing-Ting Chen Chieh-Lung Liang Shih-Hsin Yeh Shih-Peng Cheng Wen-Chien
author_facet	Wang Sing-Ting Chen Chieh-Lung Liang Shih-Hsin Yeh Shih-Peng Cheng Wen-Chien
author_sort	Wang Sing-Ting
title	Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature
title_short	Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature
title_full	Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature
title_fullStr	Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature
title_full_unstemmed	Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature
title_sort	acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: a case report and review of literature
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/cc4d1df278e2429aa432d82c2c2bec43
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Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature

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