Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease

Abstract Elevated angiotensin-converting enzyme 2 (ACE2) expression in organs that are potential targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of coronavirus disease 2019 (COVID-19) infection. Previous reports show that ACE2 alter its tissue-specific expression pat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shunichiro Tsukamoto, Hiromichi Wakui, Kengo Azushima, Takahiro Yamaji, Shingo Urate, Toru Suzuki, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Takayuki Yamada, Sho Kinguchi, Daisuke Kamimura, Akio Yamashita, Daisuke Sano, Masayuki Nakano, Tatsuo Hashimoto, Kouichi Tamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc4d3bcac09c4ff7b0e11d641e7e432c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cc4d3bcac09c4ff7b0e11d641e7e432c
record_format	dspace
spelling	oai:doaj.org-article:cc4d3bcac09c4ff7b0e11d641e7e432c2021-12-02T17:08:44ZTissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease10.1038/s41598-021-96294-82045-2322https://doaj.org/article/cc4d3bcac09c4ff7b0e11d641e7e432c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96294-8https://doaj.org/toc/2045-2322Abstract Elevated angiotensin-converting enzyme 2 (ACE2) expression in organs that are potential targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of coronavirus disease 2019 (COVID-19) infection. Previous reports show that ACE2 alter its tissue-specific expression patterns under various pathological conditions, including renal diseases. Here, we examined changes in pulmonary ACE2 expression in two mouse chronic kidney disease (CKD) models: adenine-induced (adenine mice) and aristolochic acid-induced (AA mice). We also investigated changes in pulmonary ACE2 expression due to renin–angiotensin system (RAS) blocker (olmesartan) treatment in these mice. Adenine mice showed significant renal functional decline and elevated blood pressure, compared with controls. AA mice also showed significant renal functional decline, compared with vehicles; blood pressure did not differ between groups. Renal ACE2 expression was significantly reduced in adenine mice and AA mice; pulmonary expression was unaffected. Olmesartan attenuated urinary albumin excretion in adenine mice, but did not affect renal or pulmonary ACE2 expression levels. The results suggest that the risk of COVID-19 infection may not be elevated in patients with CKD because of their stable pulmonary ACE2 expression. Moreover, RAS blockers can be used safely in treatment of COVID-19 patients with CKD.Shunichiro TsukamotoHiromichi WakuiKengo AzushimaTakahiro YamajiShingo UrateToru SuzukiEriko AbeShohei TanakaShinya TaguchiTakayuki YamadaSho KinguchiDaisuke KamimuraAkio YamashitaDaisuke SanoMasayuki NakanoTatsuo HashimotoKouichi TamuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shunichiro Tsukamoto Hiromichi Wakui Kengo Azushima Takahiro Yamaji Shingo Urate Toru Suzuki Eriko Abe Shohei Tanaka Shinya Taguchi Takayuki Yamada Sho Kinguchi Daisuke Kamimura Akio Yamashita Daisuke Sano Masayuki Nakano Tatsuo Hashimoto Kouichi Tamura Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
description	Abstract Elevated angiotensin-converting enzyme 2 (ACE2) expression in organs that are potential targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of coronavirus disease 2019 (COVID-19) infection. Previous reports show that ACE2 alter its tissue-specific expression patterns under various pathological conditions, including renal diseases. Here, we examined changes in pulmonary ACE2 expression in two mouse chronic kidney disease (CKD) models: adenine-induced (adenine mice) and aristolochic acid-induced (AA mice). We also investigated changes in pulmonary ACE2 expression due to renin–angiotensin system (RAS) blocker (olmesartan) treatment in these mice. Adenine mice showed significant renal functional decline and elevated blood pressure, compared with controls. AA mice also showed significant renal functional decline, compared with vehicles; blood pressure did not differ between groups. Renal ACE2 expression was significantly reduced in adenine mice and AA mice; pulmonary expression was unaffected. Olmesartan attenuated urinary albumin excretion in adenine mice, but did not affect renal or pulmonary ACE2 expression levels. The results suggest that the risk of COVID-19 infection may not be elevated in patients with CKD because of their stable pulmonary ACE2 expression. Moreover, RAS blockers can be used safely in treatment of COVID-19 patients with CKD.
format	article
author	Shunichiro Tsukamoto Hiromichi Wakui Kengo Azushima Takahiro Yamaji Shingo Urate Toru Suzuki Eriko Abe Shohei Tanaka Shinya Taguchi Takayuki Yamada Sho Kinguchi Daisuke Kamimura Akio Yamashita Daisuke Sano Masayuki Nakano Tatsuo Hashimoto Kouichi Tamura
author_facet	Shunichiro Tsukamoto Hiromichi Wakui Kengo Azushima Takahiro Yamaji Shingo Urate Toru Suzuki Eriko Abe Shohei Tanaka Shinya Taguchi Takayuki Yamada Sho Kinguchi Daisuke Kamimura Akio Yamashita Daisuke Sano Masayuki Nakano Tatsuo Hashimoto Kouichi Tamura
author_sort	Shunichiro Tsukamoto
title	Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
title_short	Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
title_full	Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
title_fullStr	Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
title_full_unstemmed	Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
title_sort	tissue-specific expression of the sars-cov-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc4d3bcac09c4ff7b0e11d641e7e432c
work_keys_str_mv	AT shunichirotsukamoto tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT hiromichiwakui tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT kengoazushima tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT takahiroyamaji tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT shingourate tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT torusuzuki tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT erikoabe tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT shoheitanaka tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT shinyataguchi tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT takayukiyamada tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT shokinguchi tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT daisukekamimura tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT akioyamashita tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT daisukesano tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT masayukinakano tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT tatsuohashimoto tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease AT kouichitamura tissuespecificexpressionofthesarscov2receptorangiotensinconvertingenzyme2inmousemodelsofchronickidneydisease
_version_	1718381524743618560

Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease

Ejemplares similares