Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses

Asymmetric subcellular mRNA distribution is important for local translation of neuronal mRNAs. Here the authors employed MS2 live-cell imaging and showed that the reporter mRNA containing the 3’ UTR of Rgs4 shows an anterograde transport bias, dependent on neuronal activity and the protein Staufen2,...

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Autores principales:	Karl E. Bauer, Inmaculada Segura, Imre Gaspar, Volker Scheuss, Christin Illig, Georg Ammer, Saskia Hutten, Eugénia Basyuk, Sandra M. Fernández-Moya, Janina Ehses, Edouard Bertrand, Michael A. Kiebler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc4d41928ef64ea9ba34f9e96c74913b
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spelling	oai:doaj.org-article:cc4d41928ef64ea9ba34f9e96c74913b2021-12-02T15:35:38ZLive cell imaging reveals 3′-UTR dependent mRNA sorting to synapses10.1038/s41467-019-11123-x2041-1723https://doaj.org/article/cc4d41928ef64ea9ba34f9e96c74913b2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11123-xhttps://doaj.org/toc/2041-1723Asymmetric subcellular mRNA distribution is important for local translation of neuronal mRNAs. Here the authors employed MS2 live-cell imaging and showed that the reporter mRNA containing the 3’ UTR of Rgs4 shows an anterograde transport bias, dependent on neuronal activity and the protein Staufen2, and mediates sustained mRNA recruitment to synapses.Karl E. BauerInmaculada SeguraImre GasparVolker ScheussChristin IlligGeorg AmmerSaskia HuttenEugénia BasyukSandra M. Fernández-MoyaJanina EhsesEdouard BertrandMichael A. KieblerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karl E. Bauer Inmaculada Segura Imre Gaspar Volker Scheuss Christin Illig Georg Ammer Saskia Hutten Eugénia Basyuk Sandra M. Fernández-Moya Janina Ehses Edouard Bertrand Michael A. Kiebler Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses
description	Asymmetric subcellular mRNA distribution is important for local translation of neuronal mRNAs. Here the authors employed MS2 live-cell imaging and showed that the reporter mRNA containing the 3’ UTR of Rgs4 shows an anterograde transport bias, dependent on neuronal activity and the protein Staufen2, and mediates sustained mRNA recruitment to synapses.
format	article
author	Karl E. Bauer Inmaculada Segura Imre Gaspar Volker Scheuss Christin Illig Georg Ammer Saskia Hutten Eugénia Basyuk Sandra M. Fernández-Moya Janina Ehses Edouard Bertrand Michael A. Kiebler
author_facet	Karl E. Bauer Inmaculada Segura Imre Gaspar Volker Scheuss Christin Illig Georg Ammer Saskia Hutten Eugénia Basyuk Sandra M. Fernández-Moya Janina Ehses Edouard Bertrand Michael A. Kiebler
author_sort	Karl E. Bauer
title	Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses
title_short	Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses
title_full	Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses
title_fullStr	Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses
title_full_unstemmed	Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses
title_sort	live cell imaging reveals 3′-utr dependent mrna sorting to synapses
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cc4d41928ef64ea9ba34f9e96c74913b
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Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses

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