Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model

Abstract Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD. It has been reported that beta-hydroxybutyrate (BHB), one of the main ketone bod...

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Autores principales:	Takehiko Yamanashi, Masaaki Iwata, Midori Shibushita, Kyohei Tsunetomi, Mayu Nagata, Naofumi Kajitani, Akihiko Miura, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Takahiro A. Kato, Daiki Setoyama, Yukihiko Shirayama, Ken Watanabe, Gen Shinozaki, Koichi Kaneko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc4db5e18bf94e68b1156751f8c6a098
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spelling	oai:doaj.org-article:cc4db5e18bf94e68b1156751f8c6a0982021-12-02T16:18:06ZBeta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model10.1038/s41598-020-78410-22045-2322https://doaj.org/article/cc4db5e18bf94e68b1156751f8c6a0982020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78410-2https://doaj.org/toc/2045-2322Abstract Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD. It has been reported that beta-hydroxybutyrate (BHB), one of the main ketone bodies produced, can have an anti-inflammatory and antidepressant effect. Here, we investigated the potential anti-anxiety and anti-inflammatory effects of BHB using a rodent PTSD model, induced by single prolonged stress (SPS). Male, Sprague–Dawley rats were employed in this study. Repeated administration of BHB attenuated SPS-induced anxiety-related behaviors evaluated by the elevated plus maze test. SPS increased the serum levels of TNF-α and IL-1β. In contrast, BHB administration partially attenuated the increase of serum TNF-α. These findings demonstrate that BHB exerts its anxiolytic effects, possibly by inhibiting systemic TNF-α. Hence, BHB may be a novel therapeutic candidate for the treatment of PTSD.Takehiko YamanashiMasaaki IwataMidori ShibushitaKyohei TsunetomiMayu NagataNaofumi KajitaniAkihiko MiuraRyoichi MatsuoTsuyoshi NishiguchiTakahiro A. KatoDaiki SetoyamaYukihiko ShirayamaKen WatanabeGen ShinozakiKoichi KanekoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takehiko Yamanashi Masaaki Iwata Midori Shibushita Kyohei Tsunetomi Mayu Nagata Naofumi Kajitani Akihiko Miura Ryoichi Matsuo Tsuyoshi Nishiguchi Takahiro A. Kato Daiki Setoyama Yukihiko Shirayama Ken Watanabe Gen Shinozaki Koichi Kaneko Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
description	Abstract Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD. It has been reported that beta-hydroxybutyrate (BHB), one of the main ketone bodies produced, can have an anti-inflammatory and antidepressant effect. Here, we investigated the potential anti-anxiety and anti-inflammatory effects of BHB using a rodent PTSD model, induced by single prolonged stress (SPS). Male, Sprague–Dawley rats were employed in this study. Repeated administration of BHB attenuated SPS-induced anxiety-related behaviors evaluated by the elevated plus maze test. SPS increased the serum levels of TNF-α and IL-1β. In contrast, BHB administration partially attenuated the increase of serum TNF-α. These findings demonstrate that BHB exerts its anxiolytic effects, possibly by inhibiting systemic TNF-α. Hence, BHB may be a novel therapeutic candidate for the treatment of PTSD.
format	article
author	Takehiko Yamanashi Masaaki Iwata Midori Shibushita Kyohei Tsunetomi Mayu Nagata Naofumi Kajitani Akihiko Miura Ryoichi Matsuo Tsuyoshi Nishiguchi Takahiro A. Kato Daiki Setoyama Yukihiko Shirayama Ken Watanabe Gen Shinozaki Koichi Kaneko
author_facet	Takehiko Yamanashi Masaaki Iwata Midori Shibushita Kyohei Tsunetomi Mayu Nagata Naofumi Kajitani Akihiko Miura Ryoichi Matsuo Tsuyoshi Nishiguchi Takahiro A. Kato Daiki Setoyama Yukihiko Shirayama Ken Watanabe Gen Shinozaki Koichi Kaneko
author_sort	Takehiko Yamanashi
title	Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
title_short	Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
title_full	Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
title_fullStr	Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
title_full_unstemmed	Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
title_sort	beta-hydroxybutyrate, an endogenous nlrp3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc4db5e18bf94e68b1156751f8c6a098
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Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model

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