HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the mitochondrion resulting in reduced FA beta ox...

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Autores principales:	Weinan Du, Luchang Zhang, Adina Brett-Morris, Brittany Aguila, Janos Kerner, Charles L. Hoppel, Michelle Puchowicz, Dolors Serra, Laura Herrero, Brian I. Rini, Steven Campbell, Scott M. Welford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc5068c04902403e806e57ccd56d51a2
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spelling	oai:doaj.org-article:cc5068c04902403e806e57ccd56d51a22021-12-02T17:01:18ZHIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism10.1038/s41467-017-01965-82041-1723https://doaj.org/article/cc5068c04902403e806e57ccd56d51a22017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01965-8https://doaj.org/toc/2041-1723Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the mitochondrion resulting in reduced FA beta oxidation.Weinan DuLuchang ZhangAdina Brett-MorrisBrittany AguilaJanos KernerCharles L. HoppelMichelle PuchowiczDolors SerraLaura HerreroBrian I. RiniSteven CampbellScott M. WelfordNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weinan Du Luchang Zhang Adina Brett-Morris Brittany Aguila Janos Kerner Charles L. Hoppel Michelle Puchowicz Dolors Serra Laura Herrero Brian I. Rini Steven Campbell Scott M. Welford HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
description	Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the mitochondrion resulting in reduced FA beta oxidation.
format	article
author	Weinan Du Luchang Zhang Adina Brett-Morris Brittany Aguila Janos Kerner Charles L. Hoppel Michelle Puchowicz Dolors Serra Laura Herrero Brian I. Rini Steven Campbell Scott M. Welford
author_facet	Weinan Du Luchang Zhang Adina Brett-Morris Brittany Aguila Janos Kerner Charles L. Hoppel Michelle Puchowicz Dolors Serra Laura Herrero Brian I. Rini Steven Campbell Scott M. Welford
author_sort	Weinan Du
title	HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
title_short	HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
title_full	HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
title_fullStr	HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
title_full_unstemmed	HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
title_sort	hif drives lipid deposition and cancer in ccrcc via repression of fatty acid metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cc5068c04902403e806e57ccd56d51a2
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HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

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