Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells

Here, using human cells and mouse models, the authors show that Zika virus can infect preimplantation trophectoderm. Pre-implantation infection can affect nervous system development and survival of neural progenitors, and can result in miscarriage or spontaneous abortion.

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Autores principales:	Lei Tan, Lauretta A. Lacko, Ting Zhou, Delia Tomoiaga, Romulo Hurtado, Tuo Zhang, Ana Sevilla, Aaron Zhong, Christopher E Mason, Scott Noggle, Todd Evans, Heidi Stuhlmann, Robert E. Schwartz, Shuibing Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc5622b5dfc04f5d988bdfabb453be0c
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spelling	oai:doaj.org-article:cc5622b5dfc04f5d988bdfabb453be0c2021-12-02T17:01:46ZPre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells10.1038/s41467-019-12063-22041-1723https://doaj.org/article/cc5622b5dfc04f5d988bdfabb453be0c2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12063-2https://doaj.org/toc/2041-1723Here, using human cells and mouse models, the authors show that Zika virus can infect preimplantation trophectoderm. Pre-implantation infection can affect nervous system development and survival of neural progenitors, and can result in miscarriage or spontaneous abortion.Lei TanLauretta A. LackoTing ZhouDelia TomoiagaRomulo HurtadoTuo ZhangAna SevillaAaron ZhongChristopher E MasonScott NoggleTodd EvansHeidi StuhlmannRobert E. SchwartzShuibing ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Tan Lauretta A. Lacko Ting Zhou Delia Tomoiaga Romulo Hurtado Tuo Zhang Ana Sevilla Aaron Zhong Christopher E Mason Scott Noggle Todd Evans Heidi Stuhlmann Robert E. Schwartz Shuibing Chen Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells
description	Here, using human cells and mouse models, the authors show that Zika virus can infect preimplantation trophectoderm. Pre-implantation infection can affect nervous system development and survival of neural progenitors, and can result in miscarriage or spontaneous abortion.
format	article
author	Lei Tan Lauretta A. Lacko Ting Zhou Delia Tomoiaga Romulo Hurtado Tuo Zhang Ana Sevilla Aaron Zhong Christopher E Mason Scott Noggle Todd Evans Heidi Stuhlmann Robert E. Schwartz Shuibing Chen
author_facet	Lei Tan Lauretta A. Lacko Ting Zhou Delia Tomoiaga Romulo Hurtado Tuo Zhang Ana Sevilla Aaron Zhong Christopher E Mason Scott Noggle Todd Evans Heidi Stuhlmann Robert E. Schwartz Shuibing Chen
author_sort	Lei Tan
title	Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells
title_short	Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells
title_full	Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells
title_fullStr	Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells
title_full_unstemmed	Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells
title_sort	pre- and peri-implantation zika virus infection impairs fetal development by targeting trophectoderm cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cc5622b5dfc04f5d988bdfabb453be0c
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Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells

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