Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells
Here, using human cells and mouse models, the authors show that Zika virus can infect preimplantation trophectoderm. Pre-implantation infection can affect nervous system development and survival of neural progenitors, and can result in miscarriage or spontaneous abortion.
Guardado en:
Autores principales: | Lei Tan, Lauretta A. Lacko, Ting Zhou, Delia Tomoiaga, Romulo Hurtado, Tuo Zhang, Ana Sevilla, Aaron Zhong, Christopher E Mason, Scott Noggle, Todd Evans, Heidi Stuhlmann, Robert E. Schwartz, Shuibing Chen |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/cc5622b5dfc04f5d988bdfabb453be0c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Human embryo polarization requires PLC signaling to mediate trophectoderm specification
por: Meng Zhu, et al.
Publicado: (2021) -
Limited Evidence for Infection of Urban and Peri-urban Nonhuman Primates with Zika and Chikungunya Viruses in Brazil
por: Andres Moreira-Soto, et al.
Publicado: (2018) -
Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantation.
por: Joel Dokmegang, et al.
Publicado: (2021) -
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques.
por: Sydney M Nguyen, et al.
Publicado: (2017) -
Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques
por: Diogo M. Magnani, et al.
Publicado: (2018)