Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress

Glycogen is a storage form of glucose in cells. Here, Gusarovet al. show that glycogen-derived glucose can be used to quickly regenerate the antioxidant glutathione and that inhibiting glycogen synthesis extends C. eleganslifespan, whereas glycogen accumulation drives organismal ageing in worms.

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Auteurs principaux:	Ivan Gusarov, Bibhusita Pani, Laurent Gautier, Olga Smolentseva, Svetlana Eremina, Ilya Shamovsky, Olga Katkova-Zhukotskaya, Alexander Mironov, Evgeny Nudler
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/cc5ba51eefac47af8c1cb0ac0e56b5d8
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spelling	oai:doaj.org-article:cc5ba51eefac47af8c1cb0ac0e56b5d82021-12-02T17:06:22ZGlycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress10.1038/ncomms158682041-1723https://doaj.org/article/cc5ba51eefac47af8c1cb0ac0e56b5d82017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15868https://doaj.org/toc/2041-1723Glycogen is a storage form of glucose in cells. Here, Gusarovet al. show that glycogen-derived glucose can be used to quickly regenerate the antioxidant glutathione and that inhibiting glycogen synthesis extends C. eleganslifespan, whereas glycogen accumulation drives organismal ageing in worms.Ivan GusarovBibhusita PaniLaurent GautierOlga SmolentsevaSvetlana EreminaIlya ShamovskyOlga Katkova-ZhukotskayaAlexander MironovEvgeny NudlerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ivan Gusarov Bibhusita Pani Laurent Gautier Olga Smolentseva Svetlana Eremina Ilya Shamovsky Olga Katkova-Zhukotskaya Alexander Mironov Evgeny Nudler Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress
description	Glycogen is a storage form of glucose in cells. Here, Gusarovet al. show that glycogen-derived glucose can be used to quickly regenerate the antioxidant glutathione and that inhibiting glycogen synthesis extends C. eleganslifespan, whereas glycogen accumulation drives organismal ageing in worms.
format	article
author	Ivan Gusarov Bibhusita Pani Laurent Gautier Olga Smolentseva Svetlana Eremina Ilya Shamovsky Olga Katkova-Zhukotskaya Alexander Mironov Evgeny Nudler
author_facet	Ivan Gusarov Bibhusita Pani Laurent Gautier Olga Smolentseva Svetlana Eremina Ilya Shamovsky Olga Katkova-Zhukotskaya Alexander Mironov Evgeny Nudler
author_sort	Ivan Gusarov
title	Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress
title_short	Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress
title_full	Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress
title_fullStr	Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress
title_full_unstemmed	Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress
title_sort	glycogen controls caenorhabditis elegans lifespan and resistance to oxidative stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cc5ba51eefac47af8c1cb0ac0e56b5d8
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Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress

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