Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

“Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entry in primary breast cells from healthy donors.”

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Autores principales:	Emily A. Saunderson, Peter Stepper, Jennifer J. Gomm, Lily Hoa, Adrienne Morgan, Michael D. Allen, J. Louise Jones, John G. Gribben, Tomasz P. Jurkowski, Gabriella Ficz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc5d45d93ae34cfa90c771738264e95a
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spelling	oai:doaj.org-article:cc5d45d93ae34cfa90c771738264e95a2021-12-02T17:06:05ZHit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors10.1038/s41467-017-01078-22041-1723https://doaj.org/article/cc5d45d93ae34cfa90c771738264e95a2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01078-2https://doaj.org/toc/2041-1723“Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entry in primary breast cells from healthy donors.”Emily A. SaundersonPeter StepperJennifer J. GommLily HoaAdrienne MorganMichael D. AllenJ. Louise JonesJohn G. GribbenTomasz P. JurkowskiGabriella FiczNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily A. Saunderson Peter Stepper Jennifer J. Gomm Lily Hoa Adrienne Morgan Michael D. Allen J. Louise Jones John G. Gribben Tomasz P. Jurkowski Gabriella Ficz Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
description	“Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entry in primary breast cells from healthy donors.”
format	article
author	Emily A. Saunderson Peter Stepper Jennifer J. Gomm Lily Hoa Adrienne Morgan Michael D. Allen J. Louise Jones John G. Gribben Tomasz P. Jurkowski Gabriella Ficz
author_facet	Emily A. Saunderson Peter Stepper Jennifer J. Gomm Lily Hoa Adrienne Morgan Michael D. Allen J. Louise Jones John G. Gribben Tomasz P. Jurkowski Gabriella Ficz
author_sort	Emily A. Saunderson
title	Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
title_short	Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
title_full	Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
title_fullStr	Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
title_full_unstemmed	Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
title_sort	hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cc5d45d93ae34cfa90c771738264e95a
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Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

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