Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

Mitochondrial populations in cells may consist of heteroplasmic mixtures of mtDNA types, and their evolution through development, aging and generations is central to genetic diseases. Here the authors dissect these population dynamics using a large mouse-based data set to characterise the dynamics o...

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Autores principales:	Joerg P. Burgstaller, Thomas Kolbe, Vitezslav Havlicek, Stephanie Hembach, Joanna Poulton, Jaroslav Piálek, Ralf Steinborn, Thomas Rülicke, Gottfried Brem, Nick S. Jones, Iain G. Johnston
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc6164d489974209a000641b4844da87
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spelling	oai:doaj.org-article:cc6164d489974209a000641b4844da872021-12-02T14:39:09ZLarge-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations10.1038/s41467-018-04797-22041-1723https://doaj.org/article/cc6164d489974209a000641b4844da872018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04797-2https://doaj.org/toc/2041-1723Mitochondrial populations in cells may consist of heteroplasmic mixtures of mtDNA types, and their evolution through development, aging and generations is central to genetic diseases. Here the authors dissect these population dynamics using a large mouse-based data set to characterise the dynamics of heteroplasmy mean and variance throughout life and across generations.Joerg P. BurgstallerThomas KolbeVitezslav HavlicekStephanie HembachJoanna PoultonJaroslav PiálekRalf SteinbornThomas RülickeGottfried BremNick S. JonesIain G. JohnstonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joerg P. Burgstaller Thomas Kolbe Vitezslav Havlicek Stephanie Hembach Joanna Poulton Jaroslav Piálek Ralf Steinborn Thomas Rülicke Gottfried Brem Nick S. Jones Iain G. Johnston Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations
description	Mitochondrial populations in cells may consist of heteroplasmic mixtures of mtDNA types, and their evolution through development, aging and generations is central to genetic diseases. Here the authors dissect these population dynamics using a large mouse-based data set to characterise the dynamics of heteroplasmy mean and variance throughout life and across generations.
format	article
author	Joerg P. Burgstaller Thomas Kolbe Vitezslav Havlicek Stephanie Hembach Joanna Poulton Jaroslav Piálek Ralf Steinborn Thomas Rülicke Gottfried Brem Nick S. Jones Iain G. Johnston
author_facet	Joerg P. Burgstaller Thomas Kolbe Vitezslav Havlicek Stephanie Hembach Joanna Poulton Jaroslav Piálek Ralf Steinborn Thomas Rülicke Gottfried Brem Nick S. Jones Iain G. Johnston
author_sort	Joerg P. Burgstaller
title	Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations
title_short	Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations
title_full	Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations
title_fullStr	Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations
title_full_unstemmed	Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations
title_sort	large-scale genetic analysis reveals mammalian mtdna heteroplasmy dynamics and variance increase through lifetimes and generations
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cc6164d489974209a000641b4844da87
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Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

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