Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

Jun Liu,1,* Long Huang,2,3,* Xiumei Tian,4 Xiaoming Chen,4 Yuanzhi Shao,5 Fukang Xie,3 Dihu Chen,1 Li Li21School of Electronics and Information Technology and School of Physics, 2State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, 3Department of Histology an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liu J, Huang L, Tian XM, Chen XM, Shao YZ, Xie FK, Chen DH, Li L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Upconversion nanoparticles Upconversion luminescence imaging MR imaging Photodynamic therapy Singlet oxygen Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cc62b3bd0d604c60a8732996c02a4ad9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cc62b3bd0d604c60a8732996c02a4ad9
record_format	dspace
spelling	oai:doaj.org-article:cc62b3bd0d604c60a8732996c02a4ad92021-12-02T02:10:30ZMagnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy1178-2013https://doaj.org/article/cc62b3bd0d604c60a8732996c02a4ad92016-12-01T00:00:00Zhttps://www.dovepress.com/magnetic-and-fluorescent-gd2o3yb3ln3-nanoparticles-for-simultaneous-up-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jun Liu,1,* Long Huang,2,3,* Xiumei Tian,4 Xiaoming Chen,4 Yuanzhi Shao,5 Fukang Xie,3 Dihu Chen,1 Li Li21School of Electronics and Information Technology and School of Physics, 2State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, 3Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University, 4Department of Biomedical Engineering, Guangzhou Medical University, 5State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-Sen University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd2O3) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity (r1) are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products can serve as good MRI contrast agents. The bright upconversion luminescence of the products allows their use as fluorescence nanoprobes for live cells imaging. We also utilized the luminescence-emission capability of the UCNs for the activation of a photosensitizer to achieve significant PDT results. To the best of our knowledge, this study is the first use of lanthanide-doped Gd2O3 UCNs in a theranostics application. This investigation provides a useful platform for the development of Gd2O3-based UCNs for clinical diagnosis, treatment, and imaging-guided therapy of cancer.Keywords: upconversion nanoparticles, upconversion luminescence imaging, MR imaging, photodynamic therapy, singlet oxygenLiu JHuang LTian XMChen XMShao YZXie FKChen DHLi LDove Medical PressarticleUpconversion nanoparticlesUpconversion luminescence imagingMR imagingPhotodynamic therapySinglet oxygenMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Upconversion nanoparticles Upconversion luminescence imaging MR imaging Photodynamic therapy Singlet oxygen Medicine (General) R5-920
spellingShingle	Upconversion nanoparticles Upconversion luminescence imaging MR imaging Photodynamic therapy Singlet oxygen Medicine (General) R5-920 Liu J Huang L Tian XM Chen XM Shao YZ Xie FK Chen DH Li L Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy
description	Jun Liu,1,* Long Huang,2,3,* Xiumei Tian,4 Xiaoming Chen,4 Yuanzhi Shao,5 Fukang Xie,3 Dihu Chen,1 Li Li21School of Electronics and Information Technology and School of Physics, 2State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, 3Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University, 4Department of Biomedical Engineering, Guangzhou Medical University, 5State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-Sen University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd2O3) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity (r1) are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products can serve as good MRI contrast agents. The bright upconversion luminescence of the products allows their use as fluorescence nanoprobes for live cells imaging. We also utilized the luminescence-emission capability of the UCNs for the activation of a photosensitizer to achieve significant PDT results. To the best of our knowledge, this study is the first use of lanthanide-doped Gd2O3 UCNs in a theranostics application. This investigation provides a useful platform for the development of Gd2O3-based UCNs for clinical diagnosis, treatment, and imaging-guided therapy of cancer.Keywords: upconversion nanoparticles, upconversion luminescence imaging, MR imaging, photodynamic therapy, singlet oxygen
format	article
author	Liu J Huang L Tian XM Chen XM Shao YZ Xie FK Chen DH Li L
author_facet	Liu J Huang L Tian XM Chen XM Shao YZ Xie FK Chen DH Li L
author_sort	Liu J
title	Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy
title_short	Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy
title_full	Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy
title_fullStr	Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy
title_full_unstemmed	Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy
title_sort	magnetic and fluorescent gd2o3:yb3+/ln3+ nanoparticles for simultaneous upconversion luminescence/mr dual modal imaging and nir-induced photodynamic therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/cc62b3bd0d604c60a8732996c02a4ad9
work_keys_str_mv	AT liuj magneticandfluorescentgd2o3yb3ln3nanoparticlesforsimultaneousupconversionluminescencemrdualmodalimagingandnirinducedphotodynamictherapy AT huangl magneticandfluorescentgd2o3yb3ln3nanoparticlesforsimultaneousupconversionluminescencemrdualmodalimagingandnirinducedphotodynamictherapy AT tianxm magneticandfluorescentgd2o3yb3ln3nanoparticlesforsimultaneousupconversionluminescencemrdualmodalimagingandnirinducedphotodynamictherapy AT chenxm magneticandfluorescentgd2o3yb3ln3nanoparticlesforsimultaneousupconversionluminescencemrdualmodalimagingandnirinducedphotodynamictherapy AT shaoyz magneticandfluorescentgd2o3yb3ln3nanoparticlesforsimultaneousupconversionluminescencemrdualmodalimagingandnirinducedphotodynamictherapy AT xiefk magneticandfluorescentgd2o3yb3ln3nanoparticlesforsimultaneousupconversionluminescencemrdualmodalimagingandnirinducedphotodynamictherapy AT chendh magneticandfluorescentgd2o3yb3ln3nanoparticlesforsimultaneousupconversionluminescencemrdualmodalimagingandnirinducedphotodynamictherapy AT lil magneticandfluorescentgd2o3yb3ln3nanoparticlesforsimultaneousupconversionluminescencemrdualmodalimagingandnirinducedphotodynamictherapy
_version_	1718402678232449024

Magnetic and fluorescent Gd2O3:Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

Ejemplares similares