A new heterotropic vascularized model of total urinary bladder transplantation in a rat model

Abstract This study developed a new procedure of urinary bladder transplantation on a rat model (n = 40). Heterotopic urinary bladder transplantation (n = 10) in the right groin vessels was performed. Direct urinary bladder examination, microangiography, histological analysis, and India ink injectio...

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Autores principales:	Arkadiusz Jundziłł, Henryk Witmanowski, Ewa Żary-Sikorska, Jan Adamowicz, Magdalena Bodnar, Andrzej Marszałek, Tomasz Kloskowski, Kaja Męcińska-Jundziłł, Maciej Gagat, Natalia Siedlecka, Tomasz Drewa, Marta Pokrywczyńska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc642c5981374544b093124ce3f5b4ab
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spelling	oai:doaj.org-article:cc642c5981374544b093124ce3f5b4ab2021-12-02T14:26:54ZA new heterotropic vascularized model of total urinary bladder transplantation in a rat model10.1038/s41598-021-83128-w2045-2322https://doaj.org/article/cc642c5981374544b093124ce3f5b4ab2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83128-whttps://doaj.org/toc/2045-2322Abstract This study developed a new procedure of urinary bladder transplantation on a rat model (n = 40). Heterotopic urinary bladder transplantation (n = 10) in the right groin vessels was performed. Direct urinary bladder examination, microangiography, histological analysis, and India ink injection were performed to evaluate the proposed method's functionality. Observation time was four weeks. One week after the procedure, the graft survival rate was 80%, two urinary bladders were lost due to anastomosis failure. The rest of the grafts survived two weeks without any complications. Lack of transitional epithelium or smooth muscle layer loss and lack of inflammatory process development were observed. This study was performed in order to obtain the necessary knowledge about urinary bladder transplantation. The proposed technique offers a new approach to the existing orthotropic models.Arkadiusz JundziłłHenryk WitmanowskiEwa Żary-SikorskaJan AdamowiczMagdalena BodnarAndrzej MarszałekTomasz KloskowskiKaja Męcińska-JundziłłMaciej GagatNatalia SiedleckaTomasz DrewaMarta PokrywczyńskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arkadiusz Jundziłł Henryk Witmanowski Ewa Żary-Sikorska Jan Adamowicz Magdalena Bodnar Andrzej Marszałek Tomasz Kloskowski Kaja Męcińska-Jundziłł Maciej Gagat Natalia Siedlecka Tomasz Drewa Marta Pokrywczyńska A new heterotropic vascularized model of total urinary bladder transplantation in a rat model
description	Abstract This study developed a new procedure of urinary bladder transplantation on a rat model (n = 40). Heterotopic urinary bladder transplantation (n = 10) in the right groin vessels was performed. Direct urinary bladder examination, microangiography, histological analysis, and India ink injection were performed to evaluate the proposed method's functionality. Observation time was four weeks. One week after the procedure, the graft survival rate was 80%, two urinary bladders were lost due to anastomosis failure. The rest of the grafts survived two weeks without any complications. Lack of transitional epithelium or smooth muscle layer loss and lack of inflammatory process development were observed. This study was performed in order to obtain the necessary knowledge about urinary bladder transplantation. The proposed technique offers a new approach to the existing orthotropic models.
format	article
author	Arkadiusz Jundziłł Henryk Witmanowski Ewa Żary-Sikorska Jan Adamowicz Magdalena Bodnar Andrzej Marszałek Tomasz Kloskowski Kaja Męcińska-Jundziłł Maciej Gagat Natalia Siedlecka Tomasz Drewa Marta Pokrywczyńska
author_facet	Arkadiusz Jundziłł Henryk Witmanowski Ewa Żary-Sikorska Jan Adamowicz Magdalena Bodnar Andrzej Marszałek Tomasz Kloskowski Kaja Męcińska-Jundziłł Maciej Gagat Natalia Siedlecka Tomasz Drewa Marta Pokrywczyńska
author_sort	Arkadiusz Jundziłł
title	A new heterotropic vascularized model of total urinary bladder transplantation in a rat model
title_short	A new heterotropic vascularized model of total urinary bladder transplantation in a rat model
title_full	A new heterotropic vascularized model of total urinary bladder transplantation in a rat model
title_fullStr	A new heterotropic vascularized model of total urinary bladder transplantation in a rat model
title_full_unstemmed	A new heterotropic vascularized model of total urinary bladder transplantation in a rat model
title_sort	new heterotropic vascularized model of total urinary bladder transplantation in a rat model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc642c5981374544b093124ce3f5b4ab
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A new heterotropic vascularized model of total urinary bladder transplantation in a rat model

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