Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type

Abstract Mucinous breast cancer (MBC) is a rare histological type of breast cancer characterized primarily by mucin's production and extracellular presence. MBC is usually associated with a better prognosis than other invasive breast neoplasms. Because of the low prevalence, MBC biology is not...

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Autores principales:	Michał Piotr Budzik, Marta Magdalena Fudalej, Anna Maria Badowska-Kozakiewicz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc65685bc7a84521b590d68e4bec8947
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spelling	oai:doaj.org-article:cc65685bc7a84521b590d68e4bec89472021-12-02T13:30:52ZHistopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type10.1038/s41598-021-85309-z2045-2322https://doaj.org/article/cc65685bc7a84521b590d68e4bec89472021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85309-zhttps://doaj.org/toc/2045-2322Abstract Mucinous breast cancer (MBC) is a rare histological type of breast cancer characterized primarily by mucin's production and extracellular presence. MBC is usually associated with a better prognosis than other invasive breast neoplasms. Because of the low prevalence, MBC biology is not well understood. The aim of the present study was to introduce the last 2-year experience regarding MBC pathological diagnostics in our clinical center and comparison of the obtained data with invasive breast carcinoma of no special type (NST) comprising the most common invasive breast cancer. We identified 24 MBC cases representing 3.09% of all 766 invasive breast cancers, including 15 cases of pure type and 9 mixed MBCs. The median MBC patients' age at presentation was 65.5 years. Compared to NST, MBC presented a higher T stage with a statistically larger tumor median size, although lower regional lymph node involvement, tumor histological grade and TNM stage. MBC is a rare type of breast cancer, accounting for about 4% of all diagnosed breast cancers. Our findings are consistent with those published in recent years and show significant differences between MBC and NST cancer patients and also highlight differences between pure and mixed MBC, emphasizing the essence of their differentiation. MBC is associated with a better long-term prognosis than NST and is characterized by the less aggressive biological behavior expressed through favorable clinicopathologic features in terms of tumor grade, regional lymph node involvement and hormone receptor status.Michał Piotr BudzikMarta Magdalena FudalejAnna Maria Badowska-KozakiewiczNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michał Piotr Budzik Marta Magdalena Fudalej Anna Maria Badowska-Kozakiewicz Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type
description	Abstract Mucinous breast cancer (MBC) is a rare histological type of breast cancer characterized primarily by mucin's production and extracellular presence. MBC is usually associated with a better prognosis than other invasive breast neoplasms. Because of the low prevalence, MBC biology is not well understood. The aim of the present study was to introduce the last 2-year experience regarding MBC pathological diagnostics in our clinical center and comparison of the obtained data with invasive breast carcinoma of no special type (NST) comprising the most common invasive breast cancer. We identified 24 MBC cases representing 3.09% of all 766 invasive breast cancers, including 15 cases of pure type and 9 mixed MBCs. The median MBC patients' age at presentation was 65.5 years. Compared to NST, MBC presented a higher T stage with a statistically larger tumor median size, although lower regional lymph node involvement, tumor histological grade and TNM stage. MBC is a rare type of breast cancer, accounting for about 4% of all diagnosed breast cancers. Our findings are consistent with those published in recent years and show significant differences between MBC and NST cancer patients and also highlight differences between pure and mixed MBC, emphasizing the essence of their differentiation. MBC is associated with a better long-term prognosis than NST and is characterized by the less aggressive biological behavior expressed through favorable clinicopathologic features in terms of tumor grade, regional lymph node involvement and hormone receptor status.
format	article
author	Michał Piotr Budzik Marta Magdalena Fudalej Anna Maria Badowska-Kozakiewicz
author_facet	Michał Piotr Budzik Marta Magdalena Fudalej Anna Maria Badowska-Kozakiewicz
author_sort	Michał Piotr Budzik
title	Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type
title_short	Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type
title_full	Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type
title_fullStr	Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type
title_full_unstemmed	Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type
title_sort	histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc65685bc7a84521b590d68e4bec8947
work_keys_str_mv	AT michałpiotrbudzik histopathologicalanalysisofmucinousbreastcancersubtypesandcomparisonwithinvasivecarcinomaofnospecialtype AT martamagdalenafudalej histopathologicalanalysisofmucinousbreastcancersubtypesandcomparisonwithinvasivecarcinomaofnospecialtype AT annamariabadowskakozakiewicz histopathologicalanalysisofmucinousbreastcancersubtypesandcomparisonwithinvasivecarcinomaofnospecialtype
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Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type

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