Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis

Isolated hypothyroxinemia (IH) unfavorably affects reproduction. This study aimed to evaluate retrospectively if any routinely measured clinical/laboratory parameters are associated with IH among women of childbearing age hospitalized in the endocrine department. A group of 466 female non-pregnant i...

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Autores principales:	Małgorzata Karbownik-Lewińska, Jan Stępniak, Andrzej Lewiński
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	isolated hypothyroxinemia childbearing age vitamin D deficiency insulin resistance reproduction Medicine R
Acceso en línea:	https://doaj.org/article/cc659e743de74be88bcf12bfb1cf7178
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spelling	oai:doaj.org-article:cc659e743de74be88bcf12bfb1cf71782021-11-25T18:02:17ZPotential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis10.3390/jcm102253842077-0383https://doaj.org/article/cc659e743de74be88bcf12bfb1cf71782021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5384https://doaj.org/toc/2077-0383Isolated hypothyroxinemia (IH) unfavorably affects reproduction. This study aimed to evaluate retrospectively if any routinely measured clinical/laboratory parameters are associated with IH among women of childbearing age hospitalized in the endocrine department. A group of 466 female non-pregnant inpatients (age range 13–57 years) was considered. IH (decreased free thyroxine (FT4) with normal TSH) was found in 8/466 patients (1.72%). Vitamin D deficiency (<30 ng/mL) was found in all patients with IH, whereas severe Vitamin D deficiency (<20 ng/mL) was found in 5/6. Vitamin D concentration was lower in IH females. FT4 concentration was lower in patients with severe vitamin D deficiency and correlated positively with vitamin D concentration. Insulin resistance index (IRI) was increased (>1.25) in 5/6 patients with IH. IRI was higher in IH patients and it was the only independent linear factor for IH in the univariate regression. FT4 concentration was lower in patients with increased IRI and correlated negatively with IRI. FT4 concentration correlated negatively with body mass index (BMI) and LDL cholesterol or triglycerides, and positively with HDL cholesterol or HDLC/cholesterol ratio. Vitamin D deficiency, insulin resistance and increased BMI (as potential causative factors), and abnormal lipid profile (as a possible consequence), are associated with IH in women of childbearing age. Eliminating risk factors for hypothyroxinemia may improve reproductive health.Małgorzata Karbownik-LewińskaJan StępniakAndrzej LewińskiMDPI AGarticleisolated hypothyroxinemiachildbearing agevitamin D deficiencyinsulin resistancereproductionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5384, p 5384 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	isolated hypothyroxinemia childbearing age vitamin D deficiency insulin resistance reproduction Medicine R
spellingShingle	isolated hypothyroxinemia childbearing age vitamin D deficiency insulin resistance reproduction Medicine R Małgorzata Karbownik-Lewińska Jan Stępniak Andrzej Lewiński Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis
description	Isolated hypothyroxinemia (IH) unfavorably affects reproduction. This study aimed to evaluate retrospectively if any routinely measured clinical/laboratory parameters are associated with IH among women of childbearing age hospitalized in the endocrine department. A group of 466 female non-pregnant inpatients (age range 13–57 years) was considered. IH (decreased free thyroxine (FT4) with normal TSH) was found in 8/466 patients (1.72%). Vitamin D deficiency (<30 ng/mL) was found in all patients with IH, whereas severe Vitamin D deficiency (<20 ng/mL) was found in 5/6. Vitamin D concentration was lower in IH females. FT4 concentration was lower in patients with severe vitamin D deficiency and correlated positively with vitamin D concentration. Insulin resistance index (IRI) was increased (>1.25) in 5/6 patients with IH. IRI was higher in IH patients and it was the only independent linear factor for IH in the univariate regression. FT4 concentration was lower in patients with increased IRI and correlated negatively with IRI. FT4 concentration correlated negatively with body mass index (BMI) and LDL cholesterol or triglycerides, and positively with HDL cholesterol or HDLC/cholesterol ratio. Vitamin D deficiency, insulin resistance and increased BMI (as potential causative factors), and abnormal lipid profile (as a possible consequence), are associated with IH in women of childbearing age. Eliminating risk factors for hypothyroxinemia may improve reproductive health.
format	article
author	Małgorzata Karbownik-Lewińska Jan Stępniak Andrzej Lewiński
author_facet	Małgorzata Karbownik-Lewińska Jan Stępniak Andrzej Lewiński
author_sort	Małgorzata Karbownik-Lewińska
title	Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis
title_short	Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis
title_full	Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis
title_fullStr	Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis
title_full_unstemmed	Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis
title_sort	potential risk factors for isolated hypothyroxinemia in women of childbearing age—results from retrospective analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cc659e743de74be88bcf12bfb1cf7178
work_keys_str_mv	AT małgorzatakarbowniklewinska potentialriskfactorsforisolatedhypothyroxinemiainwomenofchildbearingageresultsfromretrospectiveanalysis AT janstepniak potentialriskfactorsforisolatedhypothyroxinemiainwomenofchildbearingageresultsfromretrospectiveanalysis AT andrzejlewinski potentialriskfactorsforisolatedhypothyroxinemiainwomenofchildbearingageresultsfromretrospectiveanalysis
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Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis

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