Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity

<i>Background and Objectives</i>: Acute diverticulitis (AD) is the leading and most burdensome complication of colonic diverticulosis. However, risk factors for its development and predictors of its course are still poorly defined. In this regard, the association of a young age with a co...

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Autores principales:	Randa Taher, Yael Kopelman, Abdel-Rauf Zeina, Amir Mari, Fadi Abu Baker
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diverticulitis distal colon ethnic disparity outcome Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cc660c8f6a3c471ebdb9ecc429934c26
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spelling	oai:doaj.org-article:cc660c8f6a3c471ebdb9ecc429934c262021-11-25T18:19:06ZPredictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity10.3390/medicina571112691648-91441010-660Xhttps://doaj.org/article/cc660c8f6a3c471ebdb9ecc429934c262021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1269https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives</i>: Acute diverticulitis (AD) is the leading and most burdensome complication of colonic diverticulosis. However, risk factors for its development and predictors of its course are still poorly defined. In this regard, the association of a young age with a complicated course and worse outcome are still controversial. Moreover, little research has addressed the effect of ethnicity on the course of AD. The current study aimed to evaluate the impact of these variables on AD’s course and outcome in the diverse and unique ethnic landscape of Israel. <i>Materials and Methods</i>: We performed a retrospective review of the charts of patients with a radiologically confirmed diagnosis of AD. Patients’ outcomes and disease course, including hospitalization duration, complications, and recurrent episodes, were documented and compared among different age and ethnic groups. Multivariate analysis was performed to identify predictors of complicated AD. <i>Results:</i> Overall, 637 patients with AD were included, the majority (95%) had distal colon AD, and almost one quarter of them were aged less than 50 years. The majority of patients in the young age (<50) group were males (69.7%). Nonetheless, the rate of recurrent episodes (35.3% vs. 37.3%, <i>p</i> = 0.19), hospitalization duration (5 ± 4.7 vs. 6 ± 3.2, <i>p</i> = 0.09) and complications rate (17.3% vs. 13.7%; <i>p</i> = 0.16) were similar for both age groups. In the ethnicity group analysis, Arab minority patients had a first episode of AD at a significantly younger age compared to their Jewish counterparts (51.8 vs. 59.4 years, <i>p</i> < 0.001). However, factors such as a complicated course (16% vs. 15%; <i>p</i> = 0.08) and relapsing episode rates (33% vs. 38%; <i>p</i> = 0.36) did not differ significantly between groups. None of the variables, including young age and ethnic group, were predictors of complicated AD course in the multivariate analysis. <i>Conclusion:</i> AD is increasingly encountered in young patients, especially in ethnic minority groups, but neither ethnicity nor young age was associated with worse outcomes.Randa TaherYael KopelmanAbdel-Rauf ZeinaAmir MariFadi Abu BakerMDPI AGarticlediverticulitisdistal colonethnic disparityoutcomeMedicine (General)R5-920ENMedicina, Vol 57, Iss 1269, p 1269 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diverticulitis distal colon ethnic disparity outcome Medicine (General) R5-920
spellingShingle	diverticulitis distal colon ethnic disparity outcome Medicine (General) R5-920 Randa Taher Yael Kopelman Abdel-Rauf Zeina Amir Mari Fadi Abu Baker Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity
description	<i>Background and Objectives</i>: Acute diverticulitis (AD) is the leading and most burdensome complication of colonic diverticulosis. However, risk factors for its development and predictors of its course are still poorly defined. In this regard, the association of a young age with a complicated course and worse outcome are still controversial. Moreover, little research has addressed the effect of ethnicity on the course of AD. The current study aimed to evaluate the impact of these variables on AD’s course and outcome in the diverse and unique ethnic landscape of Israel. <i>Materials and Methods</i>: We performed a retrospective review of the charts of patients with a radiologically confirmed diagnosis of AD. Patients’ outcomes and disease course, including hospitalization duration, complications, and recurrent episodes, were documented and compared among different age and ethnic groups. Multivariate analysis was performed to identify predictors of complicated AD. <i>Results:</i> Overall, 637 patients with AD were included, the majority (95%) had distal colon AD, and almost one quarter of them were aged less than 50 years. The majority of patients in the young age (<50) group were males (69.7%). Nonetheless, the rate of recurrent episodes (35.3% vs. 37.3%, <i>p</i> = 0.19), hospitalization duration (5 ± 4.7 vs. 6 ± 3.2, <i>p</i> = 0.09) and complications rate (17.3% vs. 13.7%; <i>p</i> = 0.16) were similar for both age groups. In the ethnicity group analysis, Arab minority patients had a first episode of AD at a significantly younger age compared to their Jewish counterparts (51.8 vs. 59.4 years, <i>p</i> < 0.001). However, factors such as a complicated course (16% vs. 15%; <i>p</i> = 0.08) and relapsing episode rates (33% vs. 38%; <i>p</i> = 0.36) did not differ significantly between groups. None of the variables, including young age and ethnic group, were predictors of complicated AD course in the multivariate analysis. <i>Conclusion:</i> AD is increasingly encountered in young patients, especially in ethnic minority groups, but neither ethnicity nor young age was associated with worse outcomes.
format	article
author	Randa Taher Yael Kopelman Abdel-Rauf Zeina Amir Mari Fadi Abu Baker
author_facet	Randa Taher Yael Kopelman Abdel-Rauf Zeina Amir Mari Fadi Abu Baker
author_sort	Randa Taher
title	Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity
title_short	Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity
title_full	Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity
title_fullStr	Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity
title_full_unstemmed	Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity
title_sort	predictors of clinical course and outcomes of acute diverticulitis: the role of age and ethnicity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cc660c8f6a3c471ebdb9ecc429934c26
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Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity

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