THE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY

In this review, the reasons for successful transplantation of stem cells have been shidied. Special attention has been paid to the influence of some stem cells types on thr immune system, mainly, on activated T-lymphocytes. It has been shown, that mesenchymal and stromal stem cells in vitro blocked...

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Autores principales:	V. A. Lyashenko, D. V. Goldshtein, A. A. Rzhaninova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	allogenic transplantation stem cells immunoregulation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cc674c413a724cc0a4897e8b1ec66dd0
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spelling	oai:doaj.org-article:cc674c413a724cc0a4897e8b1ec66dd02021-11-18T08:03:42ZTHE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY1563-06252313-741X10.15789/1563-0625-2005-5-6-489-494https://doaj.org/article/cc674c413a724cc0a4897e8b1ec66dd02014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/589https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIn this review, the reasons for successful transplantation of stem cells have been shidied. Special attention has been paid to the influence of some stem cells types on thr immune system, mainly, on activated T-lymphocytes. It has been shown, that mesenchymal and stromal stem cells in vitro blocked the production of T-lymphocytes activated by allogenic cells or non-specific mitogens. Thus, contact with stem cells can impede the development of the graft immunity and inhibit the development of new T-lymphocyte clones. After the immunosuppressive therapy and stem transplantation of CD4+ population, as well as the impediment of the restoration of T-lymphocyte repertoire are observed. This effect is probably connected with immunomodulatory (similar to immunoregulatory) capacity of transferred allogenic or autologous stem cells. These studies have shown the risk of immunosuppression connected with the application of stem cells.V. A. LyashenkoD. V. GoldshteinA. A. RzhaninovaSPb RAACIarticleallogenic transplantationstem cellsimmunoregulationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 489-494 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	allogenic transplantation stem cells immunoregulation Immunologic diseases. Allergy RC581-607
spellingShingle	allogenic transplantation stem cells immunoregulation Immunologic diseases. Allergy RC581-607 V. A. Lyashenko D. V. Goldshtein A. A. Rzhaninova THE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY
description	In this review, the reasons for successful transplantation of stem cells have been shidied. Special attention has been paid to the influence of some stem cells types on thr immune system, mainly, on activated T-lymphocytes. It has been shown, that mesenchymal and stromal stem cells in vitro blocked the production of T-lymphocytes activated by allogenic cells or non-specific mitogens. Thus, contact with stem cells can impede the development of the graft immunity and inhibit the development of new T-lymphocyte clones. After the immunosuppressive therapy and stem transplantation of CD4+ population, as well as the impediment of the restoration of T-lymphocyte repertoire are observed. This effect is probably connected with immunomodulatory (similar to immunoregulatory) capacity of transferred allogenic or autologous stem cells. These studies have shown the risk of immunosuppression connected with the application of stem cells.
format	article
author	V. A. Lyashenko D. V. Goldshtein A. A. Rzhaninova
author_facet	V. A. Lyashenko D. V. Goldshtein A. A. Rzhaninova
author_sort	V. A. Lyashenko
title	THE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY
title_short	THE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY
title_full	THE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY
title_fullStr	THE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY
title_full_unstemmed	THE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY
title_sort	influence of stem cells on early stages of the graft immunity
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/cc674c413a724cc0a4897e8b1ec66dd0
work_keys_str_mv	AT valyashenko theinfluenceofstemcellsonearlystagesofthegraftimmunity AT dvgoldshtein theinfluenceofstemcellsonearlystagesofthegraftimmunity AT aarzhaninova theinfluenceofstemcellsonearlystagesofthegraftimmunity AT valyashenko influenceofstemcellsonearlystagesofthegraftimmunity AT dvgoldshtein influenceofstemcellsonearlystagesofthegraftimmunity AT aarzhaninova influenceofstemcellsonearlystagesofthegraftimmunity
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THE INFLUENCE OF STEM CELLS ON EARLY STAGES OF THE GRAFT IMMUNITY

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