Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma

Abstract This study was designed to assess 3D vs. 1D and 2D quantitative tumor analysis for prediction of overall survival (OS) in patients with Intrahepatic Cholangiocarcinoma (ICC) who underwent conventional transarterial chemoembolization (cTACE). 73 ICC patients who underwent cTACE were included...

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Autores principales:	Irvin Rexha, Fabian Laage-Gaupp, Julius Chapiro, Milena Anna Miszczuk, Johanna Maria Mijntje van Breugel, MingDe Lin, Menelaos Konstantinidis, Rafael Duran, Bernhard Gebauer, Christos Georgiades, Kelvin Hong, Nariman Nezami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc6d0d3c30ec4a84b352388775280341
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spelling	oai:doaj.org-article:cc6d0d3c30ec4a84b3523887752803412021-12-02T16:56:02ZRole of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma10.1038/s41598-021-88426-x2045-2322https://doaj.org/article/cc6d0d3c30ec4a84b3523887752803412021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88426-xhttps://doaj.org/toc/2045-2322Abstract This study was designed to assess 3D vs. 1D and 2D quantitative tumor analysis for prediction of overall survival (OS) in patients with Intrahepatic Cholangiocarcinoma (ICC) who underwent conventional transarterial chemoembolization (cTACE). 73 ICC patients who underwent cTACE were included in this retrospective analysis between Oct 2001 and Feb 2015. The overall and enhancing tumor diameters and the maximum cross-sectional and enhancing tumor areas were measured on baseline images. 3D quantitative tumor analysis was used to assess total tumor volume (TTV), enhancing tumor volume (ETV), and enhancing tumor burden (ETB) (ratio between ETV and liver volume). Patients were divided into low (LTB) and high tumor burden (HTB) groups. There was a significant separation between survival curves of the LTB and HTB groups using enhancing tumor diameter (p = 0.003), enhancing tumor area (p = 0.03), TTV (p = 0.03), and ETV (p = 0.01). Multivariate analysis showed a hazard ratio of 0.46 (95%CI: 0.27–0.78, p = 0.004) for enhancing tumor diameter, 0.56 (95% CI 0.33–0.96, p = 0.04) for enhancing tumor area, 0.58 (95%CI: 0.34–0.98, p = 0.04) for TTV, and 0.52 (95%CI: 0.30–0.91, p = 0.02) for ETV. TTV and ETV, as well as the largest enhancing tumor diameter and maximum enhancing tumor area, reliably predict the OS of patients with ICC after cTACE and could identify ICC patients who are most likely to benefit from cTACE.Irvin RexhaFabian Laage-GauppJulius ChapiroMilena Anna MiszczukJohanna Maria Mijntje van BreugelMingDe LinMenelaos KonstantinidisRafael DuranBernhard GebauerChristos GeorgiadesKelvin HongNariman NezamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irvin Rexha Fabian Laage-Gaupp Julius Chapiro Milena Anna Miszczuk Johanna Maria Mijntje van Breugel MingDe Lin Menelaos Konstantinidis Rafael Duran Bernhard Gebauer Christos Georgiades Kelvin Hong Nariman Nezami Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
description	Abstract This study was designed to assess 3D vs. 1D and 2D quantitative tumor analysis for prediction of overall survival (OS) in patients with Intrahepatic Cholangiocarcinoma (ICC) who underwent conventional transarterial chemoembolization (cTACE). 73 ICC patients who underwent cTACE were included in this retrospective analysis between Oct 2001 and Feb 2015. The overall and enhancing tumor diameters and the maximum cross-sectional and enhancing tumor areas were measured on baseline images. 3D quantitative tumor analysis was used to assess total tumor volume (TTV), enhancing tumor volume (ETV), and enhancing tumor burden (ETB) (ratio between ETV and liver volume). Patients were divided into low (LTB) and high tumor burden (HTB) groups. There was a significant separation between survival curves of the LTB and HTB groups using enhancing tumor diameter (p = 0.003), enhancing tumor area (p = 0.03), TTV (p = 0.03), and ETV (p = 0.01). Multivariate analysis showed a hazard ratio of 0.46 (95%CI: 0.27–0.78, p = 0.004) for enhancing tumor diameter, 0.56 (95% CI 0.33–0.96, p = 0.04) for enhancing tumor area, 0.58 (95%CI: 0.34–0.98, p = 0.04) for TTV, and 0.52 (95%CI: 0.30–0.91, p = 0.02) for ETV. TTV and ETV, as well as the largest enhancing tumor diameter and maximum enhancing tumor area, reliably predict the OS of patients with ICC after cTACE and could identify ICC patients who are most likely to benefit from cTACE.
format	article
author	Irvin Rexha Fabian Laage-Gaupp Julius Chapiro Milena Anna Miszczuk Johanna Maria Mijntje van Breugel MingDe Lin Menelaos Konstantinidis Rafael Duran Bernhard Gebauer Christos Georgiades Kelvin Hong Nariman Nezami
author_facet	Irvin Rexha Fabian Laage-Gaupp Julius Chapiro Milena Anna Miszczuk Johanna Maria Mijntje van Breugel MingDe Lin Menelaos Konstantinidis Rafael Duran Bernhard Gebauer Christos Georgiades Kelvin Hong Nariman Nezami
author_sort	Irvin Rexha
title	Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
title_short	Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
title_full	Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
title_fullStr	Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
title_full_unstemmed	Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
title_sort	role of 3d quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc6d0d3c30ec4a84b352388775280341
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Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma

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