Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials

With few exceptions, humans are incapable of fully recovering from severe physical trauma. Due to these limitations, the field of regenerative medicine seeks to find clinically viable ways to repair permanently damaged tissue. There are two main approaches to regenerative medicine: promoting endogen...

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Autores principales:	Maria Karkanitsa, Parinaz Fathi, Tran Ngo, Kaitlyn Sadtler
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	biomaterials immunoengineering regenerative medicine wound healing hydrogels foreign body response Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/cc6e48185316417693bf857a29d5fd9e
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id	oai:doaj.org-article:cc6e48185316417693bf857a29d5fd9e
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spelling	oai:doaj.org-article:cc6e48185316417693bf857a29d5fd9e2021-12-01T19:24:48ZMobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials2296-418510.3389/fbioe.2021.730938https://doaj.org/article/cc6e48185316417693bf857a29d5fd9e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.730938/fullhttps://doaj.org/toc/2296-4185With few exceptions, humans are incapable of fully recovering from severe physical trauma. Due to these limitations, the field of regenerative medicine seeks to find clinically viable ways to repair permanently damaged tissue. There are two main approaches to regenerative medicine: promoting endogenous repair of the wound, or transplanting a material to replace the injured tissue. In recent years, these two methods have fused with the development of biomaterials that act as a scaffold and mobilize the body’s natural healing capabilities. This process involves not only promoting stem cell behavior, but by also inducing activity of the immune system. Through understanding the immune interactions with biomaterials, we can understand how the immune system participates in regeneration and wound healing. In this review, we will focus on biomaterials that promote endogenous tissue repair, with discussion on their interactions with the immune system.Maria KarkanitsaParinaz FathiTran NgoKaitlyn SadtlerFrontiers Media S.A.articlebiomaterialsimmunoengineeringregenerative medicinewound healinghydrogelsforeign body responseBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomaterials immunoengineering regenerative medicine wound healing hydrogels foreign body response Biotechnology TP248.13-248.65
spellingShingle	biomaterials immunoengineering regenerative medicine wound healing hydrogels foreign body response Biotechnology TP248.13-248.65 Maria Karkanitsa Parinaz Fathi Tran Ngo Kaitlyn Sadtler Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
description	With few exceptions, humans are incapable of fully recovering from severe physical trauma. Due to these limitations, the field of regenerative medicine seeks to find clinically viable ways to repair permanently damaged tissue. There are two main approaches to regenerative medicine: promoting endogenous repair of the wound, or transplanting a material to replace the injured tissue. In recent years, these two methods have fused with the development of biomaterials that act as a scaffold and mobilize the body’s natural healing capabilities. This process involves not only promoting stem cell behavior, but by also inducing activity of the immune system. Through understanding the immune interactions with biomaterials, we can understand how the immune system participates in regeneration and wound healing. In this review, we will focus on biomaterials that promote endogenous tissue repair, with discussion on their interactions with the immune system.
format	article
author	Maria Karkanitsa Parinaz Fathi Tran Ngo Kaitlyn Sadtler
author_facet	Maria Karkanitsa Parinaz Fathi Tran Ngo Kaitlyn Sadtler
author_sort	Maria Karkanitsa
title	Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
title_short	Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
title_full	Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
title_fullStr	Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
title_full_unstemmed	Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
title_sort	mobilizing endogenous repair through understanding immune reaction with biomaterials
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cc6e48185316417693bf857a29d5fd9e
work_keys_str_mv	AT mariakarkanitsa mobilizingendogenousrepairthroughunderstandingimmunereactionwithbiomaterials AT parinazfathi mobilizingendogenousrepairthroughunderstandingimmunereactionwithbiomaterials AT tranngo mobilizingendogenousrepairthroughunderstandingimmunereactionwithbiomaterials AT kaitlynsadtler mobilizingendogenousrepairthroughunderstandingimmunereactionwithbiomaterials
_version_	1718404655489220608

Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials

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