Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery

Jae Yeon Joo, GilYong Park, SeongSoo A An Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam-si, Republic of Korea Abstract: In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible...

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Autores principales:	Joo JY, Park GY, An SSA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cc7179b534ec4f63bb7b7c919bd14b51
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spelling	oai:doaj.org-article:cc7179b534ec4f63bb7b7c919bd14b512021-12-02T05:10:44ZBiocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery1178-2013https://doaj.org/article/cc7179b534ec4f63bb7b7c919bd14b512015-09-01T00:00:00Zhttp://www.dovepress.com/biocompatible-and-biodegradable-fibrinogen-microspheres-for-tumor-targ-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jae Yeon Joo, GilYong Park, SeongSoo A An Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam-si, Republic of Korea Abstract: In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible materials and surface modification with targeting molecules for tumor-specific drug delivery. Fibrinogen (Fbg), an abundant glycoprotein in plasma, could be a potential candidate for developing drug carriers because of its biocompatibility and tumor-targeting property via arginine–glycine–aspartate (RGD) peptide sequences. Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow-controlled drug release, respectively. In vitro cytotoxicity tests confirmed low cytotoxicity in normal cells and high antitumor effect toward cancer cells. In addition, it was discovered that a longer linker could make the binding of cells to Fbg drug carriers easier. Therefore, DOX–linker–Fbg microspheres could be a suitable drug carrier for safer and effective drug delivery. Keywords: biocompatibility, anti-cancer drug, micro-structure, cytotoxicity, bio-conjugation, tumor targetingJoo JYPark GYAn SSADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 101-111 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Joo JY Park GY An SSA Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
description	Jae Yeon Joo, GilYong Park, SeongSoo A An Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam-si, Republic of Korea Abstract: In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible materials and surface modification with targeting molecules for tumor-specific drug delivery. Fibrinogen (Fbg), an abundant glycoprotein in plasma, could be a potential candidate for developing drug carriers because of its biocompatibility and tumor-targeting property via arginine–glycine–aspartate (RGD) peptide sequences. Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow-controlled drug release, respectively. In vitro cytotoxicity tests confirmed low cytotoxicity in normal cells and high antitumor effect toward cancer cells. In addition, it was discovered that a longer linker could make the binding of cells to Fbg drug carriers easier. Therefore, DOX–linker–Fbg microspheres could be a suitable drug carrier for safer and effective drug delivery. Keywords: biocompatibility, anti-cancer drug, micro-structure, cytotoxicity, bio-conjugation, tumor targeting
format	article
author	Joo JY Park GY An SSA
author_facet	Joo JY Park GY An SSA
author_sort	Joo JY
title	Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
title_short	Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
title_full	Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
title_fullStr	Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
title_full_unstemmed	Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
title_sort	biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/cc7179b534ec4f63bb7b7c919bd14b51
work_keys_str_mv	AT joojy biocompatibleandbiodegradablefibrinogenmicrospheresfortumortargeteddoxorubicindelivery AT parkgy biocompatibleandbiodegradablefibrinogenmicrospheresfortumortargeteddoxorubicindelivery AT anssa biocompatibleandbiodegradablefibrinogenmicrospheresfortumortargeteddoxorubicindelivery
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Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery

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