Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C

Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT5C, particularly in the production of immunoglobul...

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Autores principales:	Aleksandra Bilska, Monika Kusio-Kobiałka, Paweł S. Krawczyk, Olga Gewartowska, Bartosz Tarkowski, Kamil Kobyłecki, Dominika Nowis, Jakub Golab, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski, Seweryn Mroczek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc7369751a0649a8ac0d65c96e3806d5
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spelling	oai:doaj.org-article:cc7369751a0649a8ac0d65c96e3806d52021-12-02T14:40:27ZImmunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C10.1038/s41467-020-15835-32041-1723https://doaj.org/article/cc7369751a0649a8ac0d65c96e3806d52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15835-3https://doaj.org/toc/2041-1723Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT5C, particularly in the production of immunoglobulins.Aleksandra BilskaMonika Kusio-KobiałkaPaweł S. KrawczykOlga GewartowskaBartosz TarkowskiKamil KobyłeckiDominika NowisJakub GolabJakub GruchotaEwa BorsukAndrzej DziembowskiSeweryn MroczekNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aleksandra Bilska Monika Kusio-Kobiałka Paweł S. Krawczyk Olga Gewartowska Bartosz Tarkowski Kamil Kobyłecki Dominika Nowis Jakub Golab Jakub Gruchota Ewa Borsuk Andrzej Dziembowski Seweryn Mroczek Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
description	Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT5C, particularly in the production of immunoglobulins.
format	article
author	Aleksandra Bilska Monika Kusio-Kobiałka Paweł S. Krawczyk Olga Gewartowska Bartosz Tarkowski Kamil Kobyłecki Dominika Nowis Jakub Golab Jakub Gruchota Ewa Borsuk Andrzej Dziembowski Seweryn Mroczek
author_facet	Aleksandra Bilska Monika Kusio-Kobiałka Paweł S. Krawczyk Olga Gewartowska Bartosz Tarkowski Kamil Kobyłecki Dominika Nowis Jakub Golab Jakub Gruchota Ewa Borsuk Andrzej Dziembowski Seweryn Mroczek
author_sort	Aleksandra Bilska
title	Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
title_short	Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
title_full	Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
title_fullStr	Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
title_full_unstemmed	Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
title_sort	immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(a) polymerase tent5c
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc7369751a0649a8ac0d65c96e3806d5
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Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C

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