SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation.

SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation.

GTF2IRD1 is one of the genes implicated in Williams-Beuren syndrome, a disease caused by haploinsufficiency of certain dosage-sensitive genes within a hemizygous microdeletion of chromosome 7. GTF2IRD1 is a prime candidate for some of the major features of the disease, presumably caused by abnormall...

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Autores principales: Jocelyn Widagdo, Kylie M Taylor, Peter W Gunning, Edna C Hardeman, Stephen J Palmer
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/cc747b992ae44ab4931d6407dc917a2f
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