Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery

Abstract Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. However, the contributing factors are still unclear. We aimed to explore the relationship between betatrophin and OSA in patients undergoing Roux-en-Y ga...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhiyuan Song, Kaifeng Guo, Weijun Huang, Huajun Xu, Yupu Liu, Jian Guan, Shankai Yin, Haoyong Yu, Hongliang Yi, Jianyin Zou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc7592d2ec3f409996fcd0ea0daad7c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cc7592d2ec3f409996fcd0ea0daad7c8
record_format	dspace
spelling	oai:doaj.org-article:cc7592d2ec3f409996fcd0ea0daad7c82021-12-02T13:51:05ZDecreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery10.1038/s41598-021-81379-12045-2322https://doaj.org/article/cc7592d2ec3f409996fcd0ea0daad7c82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81379-1https://doaj.org/toc/2045-2322Abstract Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. However, the contributing factors are still unclear. We aimed to explore the relationship between betatrophin and OSA in patients undergoing Roux-en-Y gastric bypass (RYGB) surgery. Our study consisted of thirty-seven individuals with OSA and type 2 diabetes (16 males, 21 females) undergoing RYGB surgery. The polysomnography test, anthropometric results, serum betatrophin, and abdominal magnetic resonance images were evaluated both before and 1 year after RYGB surgery. Factors that may correlate with the alleviation of OSA were investigated. In our study, RYGB surgery significantly decreased apnea hypopnea index (AHI) and serum betatrophin concentration (p < 0.001). The abdominal visceral fat area, subcutaneous fat area and HOMA-IR were also significantly decreased (p < 0.001). The preoperative AHI, postoperative AHI and the change in AHI were significantly correlated with the preoperative betatrophin, postoperative betatrophin and the change in betatrophin, respectively (p < 0.05). These correlations were still significant after adjustment for other risk factors. The change in betatrophin was also independently associated with the change in minimum oxygen saturation (p < 0.001). Our data might indicate that serum betatrophin was significantly independently correlated with the improvement of OSA after bariatric surgery.Zhiyuan SongKaifeng GuoWeijun HuangHuajun XuYupu LiuJian GuanShankai YinHaoyong YuHongliang YiJianyin ZouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhiyuan Song Kaifeng Guo Weijun Huang Huajun Xu Yupu Liu Jian Guan Shankai Yin Haoyong Yu Hongliang Yi Jianyin Zou Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery
description	Abstract Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. However, the contributing factors are still unclear. We aimed to explore the relationship between betatrophin and OSA in patients undergoing Roux-en-Y gastric bypass (RYGB) surgery. Our study consisted of thirty-seven individuals with OSA and type 2 diabetes (16 males, 21 females) undergoing RYGB surgery. The polysomnography test, anthropometric results, serum betatrophin, and abdominal magnetic resonance images were evaluated both before and 1 year after RYGB surgery. Factors that may correlate with the alleviation of OSA were investigated. In our study, RYGB surgery significantly decreased apnea hypopnea index (AHI) and serum betatrophin concentration (p < 0.001). The abdominal visceral fat area, subcutaneous fat area and HOMA-IR were also significantly decreased (p < 0.001). The preoperative AHI, postoperative AHI and the change in AHI were significantly correlated with the preoperative betatrophin, postoperative betatrophin and the change in betatrophin, respectively (p < 0.05). These correlations were still significant after adjustment for other risk factors. The change in betatrophin was also independently associated with the change in minimum oxygen saturation (p < 0.001). Our data might indicate that serum betatrophin was significantly independently correlated with the improvement of OSA after bariatric surgery.
format	article
author	Zhiyuan Song Kaifeng Guo Weijun Huang Huajun Xu Yupu Liu Jian Guan Shankai Yin Haoyong Yu Hongliang Yi Jianyin Zou
author_facet	Zhiyuan Song Kaifeng Guo Weijun Huang Huajun Xu Yupu Liu Jian Guan Shankai Yin Haoyong Yu Hongliang Yi Jianyin Zou
author_sort	Zhiyuan Song
title	Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery
title_short	Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery
title_full	Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery
title_fullStr	Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery
title_full_unstemmed	Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery
title_sort	decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after roux-en-y gastric bypass surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc7592d2ec3f409996fcd0ea0daad7c8
work_keys_str_mv	AT zhiyuansong decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT kaifengguo decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT weijunhuang decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT huajunxu decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT yupuliu decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT jianguan decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT shankaiyin decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT haoyongyu decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT hongliangyi decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery AT jianyinzou decreasedserumbetatrophinmaycorrelatewiththeimprovementofobstructivesleepapneaafterrouxenygastricbypasssurgery
_version_	1718392466207408128

Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery

Ejemplares similares