Highly selective transition-metal-free transamidation of amides and amidation of esters at room temperature

Transamidation reactions usually require transition metal catalysts and/or harsh conditions. Here, the authors show a general and operationally-simple protocol for the transamidation of amides and amidation of esters by highly selective acyl cleavage with non-nucleophilic amines under mild condition...

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Autores principales: Guangchen Li, Michal Szostak
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/cc76dc0e7b4347d29b67230c62c50468
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Sumario:Transamidation reactions usually require transition metal catalysts and/or harsh conditions. Here, the authors show a general and operationally-simple protocol for the transamidation of amides and amidation of esters by highly selective acyl cleavage with non-nucleophilic amines under mild conditions.