Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides

New N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamine to form a series of novel N-[5-R-benzyl)-1,3-thiazol-2-yl]-...

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Autores principales:	Volodymyr Ya Horishny, Iryna V Drapak, Taras I Chaban, Yuriy V Ostapiuk, Vasyl S Matiychuk
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2020
Materias:	organic synthesis thiazole imidazole anticancer activity Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/cc774255fd6f40ce8aa038b406206d9d
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spelling	oai:doaj.org-article:cc774255fd6f40ce8aa038b406206d9d2021-11-15T06:08:47ZSynthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides2338-94272338-948610.22146/ijp.596https://doaj.org/article/cc774255fd6f40ce8aa038b406206d9d2020-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/596https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486New N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamine to form a series of novel N-[5-R-benzyl)-1,3-thiazol-2-yl]-4,5-dihydro-1H-imidazole-2-carboxamides with excellent yields. Anticancer activity screening of synthesized compounds was carried out within the framework of the Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA). It was shown that compounds are promising for new anticancer agents' search.Volodymyr Ya HorishnyIryna V DrapakTaras I ChabanYuriy V OstapiukVasyl S MatiychukUniversitas Gadjah Madaarticleorganic synthesisthiazoleimidazoleanticancer activityPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 150-160 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	organic synthesis thiazole imidazole anticancer activity Pharmacy and materia medica RS1-441
spellingShingle	organic synthesis thiazole imidazole anticancer activity Pharmacy and materia medica RS1-441 Volodymyr Ya Horishny Iryna V Drapak Taras I Chaban Yuriy V Ostapiuk Vasyl S Matiychuk Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides
description	New N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamine to form a series of novel N-[5-R-benzyl)-1,3-thiazol-2-yl]-4,5-dihydro-1H-imidazole-2-carboxamides with excellent yields. Anticancer activity screening of synthesized compounds was carried out within the framework of the Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA). It was shown that compounds are promising for new anticancer agents' search.
format	article
author	Volodymyr Ya Horishny Iryna V Drapak Taras I Chaban Yuriy V Ostapiuk Vasyl S Matiychuk
author_facet	Volodymyr Ya Horishny Iryna V Drapak Taras I Chaban Yuriy V Ostapiuk Vasyl S Matiychuk
author_sort	Volodymyr Ya Horishny
title	Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides
title_short	Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides
title_full	Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides
title_fullStr	Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides
title_full_unstemmed	Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides
title_sort	synthesis and antitumor properties of some new n-(5-r-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1h-imidazole-2-carboxamides
publisher	Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/cc774255fd6f40ce8aa038b406206d9d
work_keys_str_mv	AT volodymyryahorishny synthesisandantitumorpropertiesofsomenewn5rbenzyl13thiazol2yl45dihydro1himidazole2carboxamides AT irynavdrapak synthesisandantitumorpropertiesofsomenewn5rbenzyl13thiazol2yl45dihydro1himidazole2carboxamides AT tarasichaban synthesisandantitumorpropertiesofsomenewn5rbenzyl13thiazol2yl45dihydro1himidazole2carboxamides AT yuriyvostapiuk synthesisandantitumorpropertiesofsomenewn5rbenzyl13thiazol2yl45dihydro1himidazole2carboxamides AT vasylsmatiychuk synthesisandantitumorpropertiesofsomenewn5rbenzyl13thiazol2yl45dihydro1himidazole2carboxamides
_version_	1718428582038994944

Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides

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