EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS

Abstract. The effects of cholesterol (Ch) diet, i.p. administration of mevalonic acid (Mev) and their combined application upon nitric oxide (NO) production in peritoneal macrophages, as well as upon biochemical characteristics of kidney function derangements, and histological parameters of tissue a...

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Autores principales:	Ya. Sh. Schwarz, S. N. Belogorodtsev, P. N. Filimonov, G. V. Seledtsova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	nephrosclerosis macrophages cholesterol mevalonic acid nitric oxide Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cc7c8d53b675416ca19375fa0da1dbd5
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spelling	oai:doaj.org-article:cc7c8d53b675416ca19375fa0da1dbd52021-11-18T08:03:40ZEFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS1563-06252313-741X10.15789/1563-0625-2009-6-499-508https://doaj.org/article/cc7c8d53b675416ca19375fa0da1dbd52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/349https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The effects of cholesterol (Ch) diet, i.p. administration of mevalonic acid (Mev) and their combined application upon nitric oxide (NO) production in peritoneal macrophages, as well as upon biochemical characteristics of kidney function derangements, and histological parameters of tissue alterations, infiltration and fibrosis were studied in experimental model of chronic rhabdomyolysis-induced renal injury induced in C57Bl/6 mice. The effects of Ch diet, Mev and their combination on the degree of renal fibrosis were also studied in a model of unilateral ureteral obstruction. In normal animals, and, especially, in nephrotic mice, Ch diet was shown to cause a dramatic decrease of LPS-induced NO production, whereas Mev did enhance NO production significantly. Administration of Mev during Ch treatment abolished, in part, the suppressive effect of Ch. Ch diet was shown to enhance fibrotic response, without significant effect upon tissue alteration and mononuclear infiltration, whereas Mev enhanced alterative component and slightly diminished fibrosis. We conclude that Ch diet and Mev exert opposite effects upon the course and outcome of chronic nephropathy for their inhibitory (Ch) and stimulating (Mev) effect on mevalonate pathway, which is involved in the control of macrophage M1-M2 polarization.Ya. Sh. SchwarzS. N. BelogorodtsevP. N. FilimonovG. V. SeledtsovaSPb RAACIarticlenephrosclerosismacrophagescholesterolmevalonic acidnitric oxideImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 499-508 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	nephrosclerosis macrophages cholesterol mevalonic acid nitric oxide Immunologic diseases. Allergy RC581-607
spellingShingle	nephrosclerosis macrophages cholesterol mevalonic acid nitric oxide Immunologic diseases. Allergy RC581-607 Ya. Sh. Schwarz S. N. Belogorodtsev P. N. Filimonov G. V. Seledtsova EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS
description	Abstract. The effects of cholesterol (Ch) diet, i.p. administration of mevalonic acid (Mev) and their combined application upon nitric oxide (NO) production in peritoneal macrophages, as well as upon biochemical characteristics of kidney function derangements, and histological parameters of tissue alterations, infiltration and fibrosis were studied in experimental model of chronic rhabdomyolysis-induced renal injury induced in C57Bl/6 mice. The effects of Ch diet, Mev and their combination on the degree of renal fibrosis were also studied in a model of unilateral ureteral obstruction. In normal animals, and, especially, in nephrotic mice, Ch diet was shown to cause a dramatic decrease of LPS-induced NO production, whereas Mev did enhance NO production significantly. Administration of Mev during Ch treatment abolished, in part, the suppressive effect of Ch. Ch diet was shown to enhance fibrotic response, without significant effect upon tissue alteration and mononuclear infiltration, whereas Mev enhanced alterative component and slightly diminished fibrosis. We conclude that Ch diet and Mev exert opposite effects upon the course and outcome of chronic nephropathy for their inhibitory (Ch) and stimulating (Mev) effect on mevalonate pathway, which is involved in the control of macrophage M1-M2 polarization.
format	article
author	Ya. Sh. Schwarz S. N. Belogorodtsev P. N. Filimonov G. V. Seledtsova
author_facet	Ya. Sh. Schwarz S. N. Belogorodtsev P. N. Filimonov G. V. Seledtsova
author_sort	Ya. Sh. Schwarz
title	EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS
title_short	EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS
title_full	EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS
title_fullStr	EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS
title_full_unstemmed	EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS
title_sort	effects of mevalonate pathway modulators upon reactivity of macrophages in e xperimental nephrosclerosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/cc7c8d53b675416ca19375fa0da1dbd5
work_keys_str_mv	AT yashschwarz effectsofmevalonatepathwaymodulatorsuponreactivityofmacrophagesinexperimentalnephrosclerosis AT snbelogorodtsev effectsofmevalonatepathwaymodulatorsuponreactivityofmacrophagesinexperimentalnephrosclerosis AT pnfilimonov effectsofmevalonatepathwaymodulatorsuponreactivityofmacrophagesinexperimentalnephrosclerosis AT gvseledtsova effectsofmevalonatepathwaymodulatorsuponreactivityofmacrophagesinexperimentalnephrosclerosis
_version_	1718422509406126080

EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS

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