Characterization of an alternative BAK-binding site for BH3 peptides

Mitochondrial apoptosis is controlled by BCL2 family proteins, and the BH3-only proteins often act as sensors that transmit apoptotic signals. Here the authors show how the BH3-only proteins BMF and HRK can directly activate the BCL2 protein BAK and interact with BAK through an alternative binding g...

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Autores principales:	Kaiqin Ye, Wei X. Meng, Hongbin Sun, Bo Wu, Meng Chen, Yuan-Ping Pang, Jia Gao, Hongzhi Wang, Junfeng Wang, Scott H. Kaufmann, Haiming Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc7dbbdb162b4e9e8b2fa1674205cb01
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spelling	oai:doaj.org-article:cc7dbbdb162b4e9e8b2fa1674205cb012021-12-02T16:32:09ZCharacterization of an alternative BAK-binding site for BH3 peptides10.1038/s41467-020-17074-y2041-1723https://doaj.org/article/cc7dbbdb162b4e9e8b2fa1674205cb012020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17074-yhttps://doaj.org/toc/2041-1723Mitochondrial apoptosis is controlled by BCL2 family proteins, and the BH3-only proteins often act as sensors that transmit apoptotic signals. Here the authors show how the BH3-only proteins BMF and HRK can directly activate the BCL2 protein BAK and interact with BAK through an alternative binding groove.Kaiqin YeWei X. MengHongbin SunBo WuMeng ChenYuan-Ping PangJia GaoHongzhi WangJunfeng WangScott H. KaufmannHaiming DaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaiqin Ye Wei X. Meng Hongbin Sun Bo Wu Meng Chen Yuan-Ping Pang Jia Gao Hongzhi Wang Junfeng Wang Scott H. Kaufmann Haiming Dai Characterization of an alternative BAK-binding site for BH3 peptides
description	Mitochondrial apoptosis is controlled by BCL2 family proteins, and the BH3-only proteins often act as sensors that transmit apoptotic signals. Here the authors show how the BH3-only proteins BMF and HRK can directly activate the BCL2 protein BAK and interact with BAK through an alternative binding groove.
format	article
author	Kaiqin Ye Wei X. Meng Hongbin Sun Bo Wu Meng Chen Yuan-Ping Pang Jia Gao Hongzhi Wang Junfeng Wang Scott H. Kaufmann Haiming Dai
author_facet	Kaiqin Ye Wei X. Meng Hongbin Sun Bo Wu Meng Chen Yuan-Ping Pang Jia Gao Hongzhi Wang Junfeng Wang Scott H. Kaufmann Haiming Dai
author_sort	Kaiqin Ye
title	Characterization of an alternative BAK-binding site for BH3 peptides
title_short	Characterization of an alternative BAK-binding site for BH3 peptides
title_full	Characterization of an alternative BAK-binding site for BH3 peptides
title_fullStr	Characterization of an alternative BAK-binding site for BH3 peptides
title_full_unstemmed	Characterization of an alternative BAK-binding site for BH3 peptides
title_sort	characterization of an alternative bak-binding site for bh3 peptides
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc7dbbdb162b4e9e8b2fa1674205cb01
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Characterization of an alternative BAK-binding site for BH3 peptides

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