Characterization of an alternative BAK-binding site for BH3 peptides

Mitochondrial apoptosis is controlled by BCL2 family proteins, and the BH3-only proteins often act as sensors that transmit apoptotic signals. Here the authors show how the BH3-only proteins BMF and HRK can directly activate the BCL2 protein BAK and interact with BAK through an alternative binding g...

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Autores principales: Kaiqin Ye, Wei X. Meng, Hongbin Sun, Bo Wu, Meng Chen, Yuan-Ping Pang, Jia Gao, Hongzhi Wang, Junfeng Wang, Scott H. Kaufmann, Haiming Dai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cc7dbbdb162b4e9e8b2fa1674205cb01
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