Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism

In Pseudomonas aeruginosa, MexAB–OprM plays a central role in multidrug resistance by ejecting various drug compounds. Here the authors present the structure of wild-type MexAB–OprM in the presence or absence of drugs and propose mechanisms for complex formation and drug efflux.

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Autores principales:	Kenta Tsutsumi, Ryo Yonehara, Etsuko Ishizaka-Ikeda, Naoyuki Miyazaki, Shintaro Maeda, Kenji Iwasaki, Atsushi Nakagawa, Eiki Yamashita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc7f1952c6e7489598ccf9dab7aef02c
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spelling	oai:doaj.org-article:cc7f1952c6e7489598ccf9dab7aef02c2021-12-02T17:33:23ZStructures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism10.1038/s41467-019-09463-92041-1723https://doaj.org/article/cc7f1952c6e7489598ccf9dab7aef02c2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09463-9https://doaj.org/toc/2041-1723In Pseudomonas aeruginosa, MexAB–OprM plays a central role in multidrug resistance by ejecting various drug compounds. Here the authors present the structure of wild-type MexAB–OprM in the presence or absence of drugs and propose mechanisms for complex formation and drug efflux.Kenta TsutsumiRyo YoneharaEtsuko Ishizaka-IkedaNaoyuki MiyazakiShintaro MaedaKenji IwasakiAtsushi NakagawaEiki YamashitaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kenta Tsutsumi Ryo Yonehara Etsuko Ishizaka-Ikeda Naoyuki Miyazaki Shintaro Maeda Kenji Iwasaki Atsushi Nakagawa Eiki Yamashita Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
description	In Pseudomonas aeruginosa, MexAB–OprM plays a central role in multidrug resistance by ejecting various drug compounds. Here the authors present the structure of wild-type MexAB–OprM in the presence or absence of drugs and propose mechanisms for complex formation and drug efflux.
format	article
author	Kenta Tsutsumi Ryo Yonehara Etsuko Ishizaka-Ikeda Naoyuki Miyazaki Shintaro Maeda Kenji Iwasaki Atsushi Nakagawa Eiki Yamashita
author_facet	Kenta Tsutsumi Ryo Yonehara Etsuko Ishizaka-Ikeda Naoyuki Miyazaki Shintaro Maeda Kenji Iwasaki Atsushi Nakagawa Eiki Yamashita
author_sort	Kenta Tsutsumi
title	Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
title_short	Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
title_full	Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
title_fullStr	Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
title_full_unstemmed	Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
title_sort	structures of the wild-type mexab–oprm tripartite pump reveal its complex formation and drug efflux mechanism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cc7f1952c6e7489598ccf9dab7aef02c
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Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism

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