In vitro and in vivo antitumor activity of a novel pH-activated polymeric drug delivery system for doxorubicin.

In vitro and in vivo antitumor activity of a novel pH-activated polymeric drug delivery system for doxorubicin.

<h4>Background</h4>Conventional chemotherapy agent such as doxorubicin (DOX) is of limited clinical use because of its inherently low selectivity, which can lead to systemic toxicity in normal healthy tissue.<h4>Methods</h4>A pH stimuli-sensitive conjugate based on polyethyle...

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Autores principales: Menglei Huan, Bangle Zhang, Zenghui Teng, Han Cui, Jieping Wang, Xinyou Liu, Hui Xia, Siyuan Zhou, Qibing Mei
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/cc8936b69110404391661108caa659af
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