Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma

G Mangouritsas,1 N Koutropoulou,1 A Ragkousis,1 E Boutouri,1 A Diagourtas2 1Eye Clinic, General Hospital ‘‘Red Cross’’, Athens, Greece; 21st University Eye Clinic, General Hospital “G. Gennimatas”, Athens, GreeceCorrespondence: G Mangourits...

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Autores principales:	Mangouritsas G, Koutropoulou N, Ragkousis A, Boutouri E, Diagourtas A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	optical coherence tomography angiography glaucoma preperimetric glaucoma vessel density retinal nerve fiber layer ganglion cell complex Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/cc8a20085c824f7eac998110d9e345cb
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spelling	oai:doaj.org-article:cc8a20085c824f7eac998110d9e345cb2021-12-02T03:03:38ZPeripapillary Vessel Density In Unilateral Preperimetric Glaucoma1177-5483https://doaj.org/article/cc8a20085c824f7eac998110d9e345cb2019-12-01T00:00:00Zhttps://www.dovepress.com/peripapillary-vessel-density-in-unilateral-preperimetric-glaucoma-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483G Mangouritsas,1 N Koutropoulou,1 A Ragkousis,1 E Boutouri,1 A Diagourtas2 1Eye Clinic, General Hospital ‘‘Red Cross’’, Athens, Greece; 21st University Eye Clinic, General Hospital “G. Gennimatas”, Athens, GreeceCorrespondence: G MangouritsasEye Clinic, General Hospital “Red Cross”, Athanasaki 2, Athens 11526, GreeceTel +306942781166Email maguritsas@gmail.comPurpose: To investigate vessel density (VD) of radial peripapillary capillaries (RPC) and structural alterations in patients with unilateral preperimetric glaucoma (PPG) using optical coherence tomography angiography (OCTA).Methods: This cross-sectional observational study included 13 untreated patients with unilateral PPG. PPG eyes had larger excavation and abnormal thinning of retinal nerve fiber layer (RNFL) and/or ganglion cell complex (GCC) compared with fellow eyes (F). Both RNFL and GCC thickness in F were statistically within normal limits and/or borderline. The RPC VD on optic disc (idVD), of peripapillary (ppVD) and whole image (wiVD) scan area was measured. Twenty healthy eyes (H) served as controls. Structural and vascular parameters obtained by spectral-domain OCT/OCTA (Optovue; Fremont, CA) were compared between PPG, F and H.Results: Mean RNFL and GCC average thickness in microns differed significantly (p<0.001) between PPG (82.4±7.1, 81.4±5.9), F (91.0±7.1, 88.5±3.8) and H (103.5±6.0, 99.3±5.7). PPG compared with F showed significantly (p<0.001) lower mean ppVD (43.8%±3.0% versus 47.8%±3.2%) and wiVD (45.9%±3.5% versus 50.1%±3.9%). Mean ppVD (49.7%±2.4%) and wiVD (52.6%±3.0%) in H were not significantly higher than in F. Mean idVD showed no significant differences among the 3 groups. Areas under the receiver operating characteristic curves (AUROCs) for RNFL, GCC, ppVD and wiVD between PPG and H were excellent (>0.9). AUROCs between F and H demonstrated an excellent diagnostic ability for structural parameters and a poor one (<0.7) for vascular parameters.Conclusion: Affected eyes of patients with unilateral PPG demonstrated significant RPC dropout. Clinically unaffected eyes showed thinner structural parameters but no significant microvasculature differences compared with non-glaucomatous eyes. Diagnostic ability of peripapillary vascular parameters was not superior to structural measurements. Microvascular dysfunction seems to be an early but not a primary event in glaucoma continuum at the stage of undetectable visual field loss. OCTA can be useful in early glaucoma diagnosis.Keywords: optical coherence tomography angiography, glaucoma, preperimetric glaucoma, vessel density, retinal nerve fiber layer, ganglion cell complexMangouritsas GKoutropoulou NRagkousis ABoutouri EDiagourtas ADove Medical Pressarticleoptical coherence tomography angiographyglaucomapreperimetric glaucomavessel densityretinal nerve fiber layerganglion cell complexOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2511-2519 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	optical coherence tomography angiography glaucoma preperimetric glaucoma vessel density retinal nerve fiber layer ganglion cell complex Ophthalmology RE1-994
spellingShingle	optical coherence tomography angiography glaucoma preperimetric glaucoma vessel density retinal nerve fiber layer ganglion cell complex Ophthalmology RE1-994 Mangouritsas G Koutropoulou N Ragkousis A Boutouri E Diagourtas A Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma
description	G Mangouritsas,1 N Koutropoulou,1 A Ragkousis,1 E Boutouri,1 A Diagourtas2 1Eye Clinic, General Hospital ‘‘Red Cross’’, Athens, Greece; 21st University Eye Clinic, General Hospital “G. Gennimatas”, Athens, GreeceCorrespondence: G MangouritsasEye Clinic, General Hospital “Red Cross”, Athanasaki 2, Athens 11526, GreeceTel +306942781166Email maguritsas@gmail.comPurpose: To investigate vessel density (VD) of radial peripapillary capillaries (RPC) and structural alterations in patients with unilateral preperimetric glaucoma (PPG) using optical coherence tomography angiography (OCTA).Methods: This cross-sectional observational study included 13 untreated patients with unilateral PPG. PPG eyes had larger excavation and abnormal thinning of retinal nerve fiber layer (RNFL) and/or ganglion cell complex (GCC) compared with fellow eyes (F). Both RNFL and GCC thickness in F were statistically within normal limits and/or borderline. The RPC VD on optic disc (idVD), of peripapillary (ppVD) and whole image (wiVD) scan area was measured. Twenty healthy eyes (H) served as controls. Structural and vascular parameters obtained by spectral-domain OCT/OCTA (Optovue; Fremont, CA) were compared between PPG, F and H.Results: Mean RNFL and GCC average thickness in microns differed significantly (p<0.001) between PPG (82.4±7.1, 81.4±5.9), F (91.0±7.1, 88.5±3.8) and H (103.5±6.0, 99.3±5.7). PPG compared with F showed significantly (p<0.001) lower mean ppVD (43.8%±3.0% versus 47.8%±3.2%) and wiVD (45.9%±3.5% versus 50.1%±3.9%). Mean ppVD (49.7%±2.4%) and wiVD (52.6%±3.0%) in H were not significantly higher than in F. Mean idVD showed no significant differences among the 3 groups. Areas under the receiver operating characteristic curves (AUROCs) for RNFL, GCC, ppVD and wiVD between PPG and H were excellent (>0.9). AUROCs between F and H demonstrated an excellent diagnostic ability for structural parameters and a poor one (<0.7) for vascular parameters.Conclusion: Affected eyes of patients with unilateral PPG demonstrated significant RPC dropout. Clinically unaffected eyes showed thinner structural parameters but no significant microvasculature differences compared with non-glaucomatous eyes. Diagnostic ability of peripapillary vascular parameters was not superior to structural measurements. Microvascular dysfunction seems to be an early but not a primary event in glaucoma continuum at the stage of undetectable visual field loss. OCTA can be useful in early glaucoma diagnosis.Keywords: optical coherence tomography angiography, glaucoma, preperimetric glaucoma, vessel density, retinal nerve fiber layer, ganglion cell complex
format	article
author	Mangouritsas G Koutropoulou N Ragkousis A Boutouri E Diagourtas A
author_facet	Mangouritsas G Koutropoulou N Ragkousis A Boutouri E Diagourtas A
author_sort	Mangouritsas G
title	Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma
title_short	Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma
title_full	Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma
title_fullStr	Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma
title_full_unstemmed	Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma
title_sort	peripapillary vessel density in unilateral preperimetric glaucoma
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/cc8a20085c824f7eac998110d9e345cb
work_keys_str_mv	AT mangouritsasg peripapillaryvesseldensityinunilateralpreperimetricglaucoma AT koutropouloun peripapillaryvesseldensityinunilateralpreperimetricglaucoma AT ragkousisa peripapillaryvesseldensityinunilateralpreperimetricglaucoma AT boutourie peripapillaryvesseldensityinunilateralpreperimetricglaucoma AT diagourtasa peripapillaryvesseldensityinunilateralpreperimetricglaucoma
_version_	1718402008422023168

Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma

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