Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis

Abstract Thrombosis is a major cause of several diseases, i.e. myocardial infarction, cerebral stroke and pulmonary embolism. Thrombolytic therapies are required to induce fast and efficient recanalization of occluded vessels. To evaluate the in vitro efficacy of these thrombolytic strategies, measu...

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Autores principales:	Laurent Auboire, Jean-Michel Escoffre, Damien Fouan, Jean-René Jacquet, Frédéric Ossant, Jean-Marc Grégoire, Ayache Bouakaz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc8c5dd856204a618b2f80b9762baaf7
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spelling	oai:doaj.org-article:cc8c5dd856204a618b2f80b9762baaf72021-12-02T16:06:44ZEvaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis10.1038/s41598-017-06089-z2045-2322https://doaj.org/article/cc8c5dd856204a618b2f80b9762baaf72017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06089-zhttps://doaj.org/toc/2045-2322Abstract Thrombosis is a major cause of several diseases, i.e. myocardial infarction, cerebral stroke and pulmonary embolism. Thrombolytic therapies are required to induce fast and efficient recanalization of occluded vessels. To evaluate the in vitro efficacy of these thrombolytic strategies, measuring clot dissolution is essential. This study aimed to evaluate and validate high resolution ultrasound as a tool to assess the exact volume of clots in 3D and in real time during in vitro thrombolytic drug testing. This new method was validated by measuring the effects of concentration range of recombinant tissue type plasminogen activator on a blood clot during complete occlusion or 70% stenosis of a vessel. This study shows that high resolution ultrasound imaging allows for a real-time assessment of the 3D volume of a blood clot with negligible inter- and intra-operator variabilities. The conclusions drawn from this study demonstrate the promising potential of high resolution ultrasound imaging for the in vitro assessment of new thrombolytic drugs.Laurent AuboireJean-Michel EscoffreDamien FouanJean-René JacquetFrédéric OssantJean-Marc GrégoireAyache BouakazNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laurent Auboire Jean-Michel Escoffre Damien Fouan Jean-René Jacquet Frédéric Ossant Jean-Marc Grégoire Ayache Bouakaz Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis
description	Abstract Thrombosis is a major cause of several diseases, i.e. myocardial infarction, cerebral stroke and pulmonary embolism. Thrombolytic therapies are required to induce fast and efficient recanalization of occluded vessels. To evaluate the in vitro efficacy of these thrombolytic strategies, measuring clot dissolution is essential. This study aimed to evaluate and validate high resolution ultrasound as a tool to assess the exact volume of clots in 3D and in real time during in vitro thrombolytic drug testing. This new method was validated by measuring the effects of concentration range of recombinant tissue type plasminogen activator on a blood clot during complete occlusion or 70% stenosis of a vessel. This study shows that high resolution ultrasound imaging allows for a real-time assessment of the 3D volume of a blood clot with negligible inter- and intra-operator variabilities. The conclusions drawn from this study demonstrate the promising potential of high resolution ultrasound imaging for the in vitro assessment of new thrombolytic drugs.
format	article
author	Laurent Auboire Jean-Michel Escoffre Damien Fouan Jean-René Jacquet Frédéric Ossant Jean-Marc Grégoire Ayache Bouakaz
author_facet	Laurent Auboire Jean-Michel Escoffre Damien Fouan Jean-René Jacquet Frédéric Ossant Jean-Marc Grégoire Ayache Bouakaz
author_sort	Laurent Auboire
title	Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis
title_short	Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis
title_full	Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis
title_fullStr	Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis
title_full_unstemmed	Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis
title_sort	evaluation of high resolution ultrasound as a tool for assessing the 3d volume of blood clots during in vitro thrombolysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cc8c5dd856204a618b2f80b9762baaf7
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Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis

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