Pregnancy as a Risk Factor of Severe COVID-19

Since first being identified in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an etiological agent behind Coronavirus disease 19 (COVID-19), has caused three waves of a global pandemic, with a fourth in progress. Despite its high percentage of asymptomatic and low-sy...

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Autores principales:	Aleksander Celewicz, Marta Celewicz, Michał Michalczyk, Paula Woźniakowska-Gondek, Kamila Krejczy, Marcin Misiek, Rafał Rzepka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SAR-CoV-2 COVID-19 pregnancy vaccine Medicine R
Acceso en línea:	https://doaj.org/article/cc8c7b7a84ad448289c384a6a0c58c41
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spelling	oai:doaj.org-article:cc8c7b7a84ad448289c384a6a0c58c412021-11-25T18:03:01ZPregnancy as a Risk Factor of Severe COVID-1910.3390/jcm102254582077-0383https://doaj.org/article/cc8c7b7a84ad448289c384a6a0c58c412021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5458https://doaj.org/toc/2077-0383Since first being identified in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an etiological agent behind Coronavirus disease 19 (COVID-19), has caused three waves of a global pandemic, with a fourth in progress. Despite its high percentage of asymptomatic and low-symptomatic courses of illness, the SARS-CoV-2 pandemic has claimed a higher death toll than the SARS-CoV and MERS-CoV epidemics because of its high infectivity when compared to the other coronaviruses. High COVID-19 mortality is associated with age and other coexisting morbidities, as well as healthcare quality. According to several studies, pregnant women are at a higher risk of severe COVID-19 infection and adverse pregnancy outcomes (caesarean delivery, pre-term birth, low birth weight, preeclampsia, ICU admission, and need for mechanical ventilation). In our review of recent literature, we focused on the effects of COVID-19 in pregnant women, emphasizing the subcellular pathophysiology of SARS-CoV-2. In this paper, we concentrate on the pathophysiology of sub-cellular changes in COVID-19 and endeavor to highlight the aspects that manifest in physiological pregnancy and potentially create a higher risk of SARS-CoV-2 infection and acute COVID-19 symptoms. Understanding how pregnancy-associated changes can cause a synergistic effect with COVID-19 may point us in the right direction for future prophylaxis and treatment for women undergoing COVID-19 during pregnancy.Aleksander CelewiczMarta CelewiczMichał MichalczykPaula Woźniakowska-GondekKamila KrejczyMarcin MisiekRafał RzepkaMDPI AGarticleSAR-CoV-2COVID-19pregnancyvaccineMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5458, p 5458 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SAR-CoV-2 COVID-19 pregnancy vaccine Medicine R
spellingShingle	SAR-CoV-2 COVID-19 pregnancy vaccine Medicine R Aleksander Celewicz Marta Celewicz Michał Michalczyk Paula Woźniakowska-Gondek Kamila Krejczy Marcin Misiek Rafał Rzepka Pregnancy as a Risk Factor of Severe COVID-19
description	Since first being identified in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an etiological agent behind Coronavirus disease 19 (COVID-19), has caused three waves of a global pandemic, with a fourth in progress. Despite its high percentage of asymptomatic and low-symptomatic courses of illness, the SARS-CoV-2 pandemic has claimed a higher death toll than the SARS-CoV and MERS-CoV epidemics because of its high infectivity when compared to the other coronaviruses. High COVID-19 mortality is associated with age and other coexisting morbidities, as well as healthcare quality. According to several studies, pregnant women are at a higher risk of severe COVID-19 infection and adverse pregnancy outcomes (caesarean delivery, pre-term birth, low birth weight, preeclampsia, ICU admission, and need for mechanical ventilation). In our review of recent literature, we focused on the effects of COVID-19 in pregnant women, emphasizing the subcellular pathophysiology of SARS-CoV-2. In this paper, we concentrate on the pathophysiology of sub-cellular changes in COVID-19 and endeavor to highlight the aspects that manifest in physiological pregnancy and potentially create a higher risk of SARS-CoV-2 infection and acute COVID-19 symptoms. Understanding how pregnancy-associated changes can cause a synergistic effect with COVID-19 may point us in the right direction for future prophylaxis and treatment for women undergoing COVID-19 during pregnancy.
format	article
author	Aleksander Celewicz Marta Celewicz Michał Michalczyk Paula Woźniakowska-Gondek Kamila Krejczy Marcin Misiek Rafał Rzepka
author_facet	Aleksander Celewicz Marta Celewicz Michał Michalczyk Paula Woźniakowska-Gondek Kamila Krejczy Marcin Misiek Rafał Rzepka
author_sort	Aleksander Celewicz
title	Pregnancy as a Risk Factor of Severe COVID-19
title_short	Pregnancy as a Risk Factor of Severe COVID-19
title_full	Pregnancy as a Risk Factor of Severe COVID-19
title_fullStr	Pregnancy as a Risk Factor of Severe COVID-19
title_full_unstemmed	Pregnancy as a Risk Factor of Severe COVID-19
title_sort	pregnancy as a risk factor of severe covid-19
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cc8c7b7a84ad448289c384a6a0c58c41
work_keys_str_mv	AT aleksandercelewicz pregnancyasariskfactorofseverecovid19 AT martacelewicz pregnancyasariskfactorofseverecovid19 AT michałmichalczyk pregnancyasariskfactorofseverecovid19 AT paulawozniakowskagondek pregnancyasariskfactorofseverecovid19 AT kamilakrejczy pregnancyasariskfactorofseverecovid19 AT marcinmisiek pregnancyasariskfactorofseverecovid19 AT rafałrzepka pregnancyasariskfactorofseverecovid19
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Pregnancy as a Risk Factor of Severe COVID-19

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