Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study

Driving pressure (ΔP) and mechanical power (MP) are associated with outcomes in critically ill patients, irrespective of the presence of Acute Respiratory Distress Syndrome (ARDS). INTELLiVENT-ASV, a fully automated ventilatory mode, controls the settings that affect ΔP and MP. This study compared t...

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Autores principales:	Laura A. Buiteman-Kruizinga, Hassan E. Mkadmi, Ary Serpa Neto, Matthijs D. Kruizinga, Michela Botta, Marcus J. Schultz, Frederique Paulus, Pim L.J. van der Heiden
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 ARDS automated ventilation closed-loop ventilation INTELLiVENT-ASV intensity of ventilation Medicine R
Acceso en línea:	https://doaj.org/article/cc9028247f804cc8b78df72338cf4a6e
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spelling	oai:doaj.org-article:cc9028247f804cc8b78df72338cf4a6e2021-11-25T18:02:31ZEffect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study10.3390/jcm102254092077-0383https://doaj.org/article/cc9028247f804cc8b78df72338cf4a6e2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5409https://doaj.org/toc/2077-0383Driving pressure (ΔP) and mechanical power (MP) are associated with outcomes in critically ill patients, irrespective of the presence of Acute Respiratory Distress Syndrome (ARDS). INTELLiVENT-ASV, a fully automated ventilatory mode, controls the settings that affect ΔP and MP. This study compared the intensity of ventilation (ΔP and MP) with INTELLiVENT-ASV versus conventional ventilation in a cohort of COVID-19 ARDS patients in two intensive care units in the Netherlands. The coprimary endpoints were ΔP and MP before and after converting from conventional ventilation to INTELLiVENT-ASV. Compared to conventional ventilation, INTELLiVENT-ASV delivered ventilation with a lower ΔP and less MP. With conventional ventilation, ΔP was 13 cmH<sub>2</sub>O, and MP was 21.5 and 24.8 J/min, whereas with INTELLiVENT-ASV, ΔP was 11 and 10 cmH<sub>2</sub>O (mean difference –2 cm H2O (95 %CI –2.5 to –1.2 cm H<sub>2</sub>O), <i>p</i> < 0.001) and MP was 18.8 and 17.5 J/min (mean difference –7.3 J/Min (95% CI –8.8 to –5.8 J/min), <i>p</i> < 0.001). Conversion from conventional ventilation to INTELLiVENT-ASV resulted in a lower intensity of ventilation. These findings may favor the use of INTELLiVENT-ASV in COVID-19 ARDS patients, but future studies remain needed to see if the reduction in the intensity of ventilation translates into clinical benefits.Laura A. Buiteman-KruizingaHassan E. MkadmiAry Serpa NetoMatthijs D. KruizingaMichela BottaMarcus J. SchultzFrederique PaulusPim L.J. van der HeidenMDPI AGarticleCOVID-19ARDSautomated ventilationclosed-loop ventilationINTELLiVENT-ASVintensity of ventilationMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5409, p 5409 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 ARDS automated ventilation closed-loop ventilation INTELLiVENT-ASV intensity of ventilation Medicine R
spellingShingle	COVID-19 ARDS automated ventilation closed-loop ventilation INTELLiVENT-ASV intensity of ventilation Medicine R Laura A. Buiteman-Kruizinga Hassan E. Mkadmi Ary Serpa Neto Matthijs D. Kruizinga Michela Botta Marcus J. Schultz Frederique Paulus Pim L.J. van der Heiden Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study
description	Driving pressure (ΔP) and mechanical power (MP) are associated with outcomes in critically ill patients, irrespective of the presence of Acute Respiratory Distress Syndrome (ARDS). INTELLiVENT-ASV, a fully automated ventilatory mode, controls the settings that affect ΔP and MP. This study compared the intensity of ventilation (ΔP and MP) with INTELLiVENT-ASV versus conventional ventilation in a cohort of COVID-19 ARDS patients in two intensive care units in the Netherlands. The coprimary endpoints were ΔP and MP before and after converting from conventional ventilation to INTELLiVENT-ASV. Compared to conventional ventilation, INTELLiVENT-ASV delivered ventilation with a lower ΔP and less MP. With conventional ventilation, ΔP was 13 cmH<sub>2</sub>O, and MP was 21.5 and 24.8 J/min, whereas with INTELLiVENT-ASV, ΔP was 11 and 10 cmH<sub>2</sub>O (mean difference –2 cm H2O (95 %CI –2.5 to –1.2 cm H<sub>2</sub>O), <i>p</i> < 0.001) and MP was 18.8 and 17.5 J/min (mean difference –7.3 J/Min (95% CI –8.8 to –5.8 J/min), <i>p</i> < 0.001). Conversion from conventional ventilation to INTELLiVENT-ASV resulted in a lower intensity of ventilation. These findings may favor the use of INTELLiVENT-ASV in COVID-19 ARDS patients, but future studies remain needed to see if the reduction in the intensity of ventilation translates into clinical benefits.
format	article
author	Laura A. Buiteman-Kruizinga Hassan E. Mkadmi Ary Serpa Neto Matthijs D. Kruizinga Michela Botta Marcus J. Schultz Frederique Paulus Pim L.J. van der Heiden
author_facet	Laura A. Buiteman-Kruizinga Hassan E. Mkadmi Ary Serpa Neto Matthijs D. Kruizinga Michela Botta Marcus J. Schultz Frederique Paulus Pim L.J. van der Heiden
author_sort	Laura A. Buiteman-Kruizinga
title	Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study
title_short	Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study
title_full	Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study
title_fullStr	Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study
title_full_unstemmed	Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study
title_sort	effect of intellivent-asv versus conventional ventilation on ventilation intensity in patients with covid-19 ards—an observational study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cc9028247f804cc8b78df72338cf4a6e
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Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study

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