Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

The role of Polycomb Repressive Complex 1 (PRC1) is well described in development. Here, the authors investigate canonical PRC1’s regulation of transcriptional programs in breast cancer where, in addition to its repressive function, it is also recruited to oncogenic active enhancers to regulate enha...

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Autores principales:	Ho Lam Chan, Felipe Beckedorff, Yusheng Zhang, Jenaro Garcia-Huidobro, Hua Jiang, Antonio Colaprico, Daniel Bilbao, Maria E. Figueroa, John LaCava, Ramin Shiekhattar, Lluis Morey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc957fd0d811463b9e87699141c6c633
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spelling	oai:doaj.org-article:cc957fd0d811463b9e87699141c6c6332021-12-02T14:41:28ZPolycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms10.1038/s41467-018-05728-x2041-1723https://doaj.org/article/cc957fd0d811463b9e87699141c6c6332018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05728-xhttps://doaj.org/toc/2041-1723The role of Polycomb Repressive Complex 1 (PRC1) is well described in development. Here, the authors investigate canonical PRC1’s regulation of transcriptional programs in breast cancer where, in addition to its repressive function, it is also recruited to oncogenic active enhancers to regulate enhancer activity and chromatin accessibility.Ho Lam ChanFelipe BeckedorffYusheng ZhangJenaro Garcia-HuidobroHua JiangAntonio ColapricoDaniel BilbaoMaria E. FigueroaJohn LaCavaRamin ShiekhattarLluis MoreyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ho Lam Chan Felipe Beckedorff Yusheng Zhang Jenaro Garcia-Huidobro Hua Jiang Antonio Colaprico Daniel Bilbao Maria E. Figueroa John LaCava Ramin Shiekhattar Lluis Morey Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
description	The role of Polycomb Repressive Complex 1 (PRC1) is well described in development. Here, the authors investigate canonical PRC1’s regulation of transcriptional programs in breast cancer where, in addition to its repressive function, it is also recruited to oncogenic active enhancers to regulate enhancer activity and chromatin accessibility.
format	article
author	Ho Lam Chan Felipe Beckedorff Yusheng Zhang Jenaro Garcia-Huidobro Hua Jiang Antonio Colaprico Daniel Bilbao Maria E. Figueroa John LaCava Ramin Shiekhattar Lluis Morey
author_facet	Ho Lam Chan Felipe Beckedorff Yusheng Zhang Jenaro Garcia-Huidobro Hua Jiang Antonio Colaprico Daniel Bilbao Maria E. Figueroa John LaCava Ramin Shiekhattar Lluis Morey
author_sort	Ho Lam Chan
title	Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
title_short	Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
title_full	Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
title_fullStr	Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
title_full_unstemmed	Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
title_sort	polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cc957fd0d811463b9e87699141c6c633
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Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

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