Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

The role of Polycomb Repressive Complex 1 (PRC1) is well described in development. Here, the authors investigate canonical PRC1’s regulation of transcriptional programs in breast cancer where, in addition to its repressive function, it is also recruited to oncogenic active enhancers to regulate enha...

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Autores principales: Ho Lam Chan, Felipe Beckedorff, Yusheng Zhang, Jenaro Garcia-Huidobro, Hua Jiang, Antonio Colaprico, Daniel Bilbao, Maria E. Figueroa, John LaCava, Ramin Shiekhattar, Lluis Morey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/cc957fd0d811463b9e87699141c6c633
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