Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey

Abstract To explore the association between bacterial vaginosis (BV) and periodontitis (PD) and to determine whether PD and BV might be linked with systemic serum alterations. We used the National Health and Nutrition Examination Survey 2001–2004, with women aged 18–49 years old and diagnosed with o...

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Autores principales:	Cláudia Escalda, João Botelho, José João Mendes, Vanessa Machado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc99738794754b8ea7ed6c1233292b22
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spelling	oai:doaj.org-article:cc99738794754b8ea7ed6c1233292b222021-12-02T15:23:01ZAssociation of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey10.1038/s41598-020-79496-42045-2322https://doaj.org/article/cc99738794754b8ea7ed6c1233292b222021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79496-4https://doaj.org/toc/2045-2322Abstract To explore the association between bacterial vaginosis (BV) and periodontitis (PD) and to determine whether PD and BV might be linked with systemic serum alterations. We used the National Health and Nutrition Examination Survey 2001–2004, with women aged 18–49 years old and diagnosed with or without BV according to Nugent’s method. PD was defined according to the 2012 case definition. We compared serum counts according to the presence of PD and the presence of BV. Multivariable regression was used to explore and identify relevant variables towards the presence of BV. 961 women fulfilled the inclusion criteria. In women with BV, PD was associated with higher inflammation, characterized by increased white blood cells (p = 0.006) and lymphocyte (p = 0.009) counts. Predictive models presented a statistically significant association between PD and BV [Odds Ratio (OD) = 1.69, 95% Confidence Interval (CI): 1.09–2.61 for periodontitis; OD = 2.37, 95% CI: 1.30–4.29 for severe PD]. Fully adjusted models for age, smoking, body mass index, diabetes mellitus and number of systemic conditions reinforced this association [OD = 1.71, 95% CI: 1.06–2.76 for PD; OD = 2.21, 95% CI: 1.15–4.25 for severe PD]. An association between BV and PD is conceivable. PD was associated with higher systemic markers of inflammation in women with BV. Our data is novel and could serve as a foundation to guide future studies in the confirmation of this association and the underlying mechanisms.Cláudia EscaldaJoão BotelhoJosé João MendesVanessa MachadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cláudia Escalda João Botelho José João Mendes Vanessa Machado Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey
description	Abstract To explore the association between bacterial vaginosis (BV) and periodontitis (PD) and to determine whether PD and BV might be linked with systemic serum alterations. We used the National Health and Nutrition Examination Survey 2001–2004, with women aged 18–49 years old and diagnosed with or without BV according to Nugent’s method. PD was defined according to the 2012 case definition. We compared serum counts according to the presence of PD and the presence of BV. Multivariable regression was used to explore and identify relevant variables towards the presence of BV. 961 women fulfilled the inclusion criteria. In women with BV, PD was associated with higher inflammation, characterized by increased white blood cells (p = 0.006) and lymphocyte (p = 0.009) counts. Predictive models presented a statistically significant association between PD and BV [Odds Ratio (OD) = 1.69, 95% Confidence Interval (CI): 1.09–2.61 for periodontitis; OD = 2.37, 95% CI: 1.30–4.29 for severe PD]. Fully adjusted models for age, smoking, body mass index, diabetes mellitus and number of systemic conditions reinforced this association [OD = 1.71, 95% CI: 1.06–2.76 for PD; OD = 2.21, 95% CI: 1.15–4.25 for severe PD]. An association between BV and PD is conceivable. PD was associated with higher systemic markers of inflammation in women with BV. Our data is novel and could serve as a foundation to guide future studies in the confirmation of this association and the underlying mechanisms.
format	article
author	Cláudia Escalda João Botelho José João Mendes Vanessa Machado
author_facet	Cláudia Escalda João Botelho José João Mendes Vanessa Machado
author_sort	Cláudia Escalda
title	Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey
title_short	Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey
title_full	Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey
title_fullStr	Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey
title_full_unstemmed	Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey
title_sort	association of bacterial vaginosis with periodontitis in a cross-sectional american nationwide survey
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc99738794754b8ea7ed6c1233292b22
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Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey

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