Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells

Cancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that...

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Autores principales:	Dah-Jiun Fu, Lianghai Wang, Fouad K. Chouairi, Ian M. Rose, Danysh A. Abetov, Andrew D. Miller, Robert J. Yamulla, John C. Schimenti, Andrea Flesken-Nikitin, Alexander Yu. Nikitin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc9b087fae6a467297a9cdf23f9d6ec2
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spelling	oai:doaj.org-article:cc9b087fae6a467297a9cdf23f9d6ec22021-12-02T14:40:43ZGastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells10.1038/s41467-019-13847-22041-1723https://doaj.org/article/cc9b087fae6a467297a9cdf23f9d6ec22020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13847-2https://doaj.org/toc/2041-1723Cancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that contains a large pool of osteopontin responsive Lgr5-CD44+ cells.Dah-Jiun FuLianghai WangFouad K. ChouairiIan M. RoseDanysh A. AbetovAndrew D. MillerRobert J. YamullaJohn C. SchimentiAndrea Flesken-NikitinAlexander Yu. NikitinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dah-Jiun Fu Lianghai Wang Fouad K. Chouairi Ian M. Rose Danysh A. Abetov Andrew D. Miller Robert J. Yamulla John C. Schimenti Andrea Flesken-Nikitin Alexander Yu. Nikitin Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells
description	Cancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that contains a large pool of osteopontin responsive Lgr5-CD44+ cells.
format	article
author	Dah-Jiun Fu Lianghai Wang Fouad K. Chouairi Ian M. Rose Danysh A. Abetov Andrew D. Miller Robert J. Yamulla John C. Schimenti Andrea Flesken-Nikitin Alexander Yu. Nikitin
author_facet	Dah-Jiun Fu Lianghai Wang Fouad K. Chouairi Ian M. Rose Danysh A. Abetov Andrew D. Miller Robert J. Yamulla John C. Schimenti Andrea Flesken-Nikitin Alexander Yu. Nikitin
author_sort	Dah-Jiun Fu
title	Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells
title_short	Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells
title_full	Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells
title_fullStr	Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells
title_full_unstemmed	Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells
title_sort	gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive lgr5−cd44+ cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc9b087fae6a467297a9cdf23f9d6ec2
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Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells

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