Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells

Cancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that...

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Autores principales: Dah-Jiun Fu, Lianghai Wang, Fouad K. Chouairi, Ian M. Rose, Danysh A. Abetov, Andrew D. Miller, Robert J. Yamulla, John C. Schimenti, Andrea Flesken-Nikitin, Alexander Yu. Nikitin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cc9b087fae6a467297a9cdf23f9d6ec2
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