Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders

Brain disorders are associated with network dysfunctions that are not addressed by conventional drug screens. Here, the authors use high-throughput functional imaging of brain activity in zebrafish larvae to study the effects of individual drugs on network connectivity and demonstrate an algorithm t...

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Autores principales: Mostafa Ghannad-Rezaie, Peter M. Eimon, Yuelong Wu, Mehmet Fatih Yanik
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/cc9b629481084e6bb8ce6ed68a64b036
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Sumario:Brain disorders are associated with network dysfunctions that are not addressed by conventional drug screens. Here, the authors use high-throughput functional imaging of brain activity in zebrafish larvae to study the effects of individual drugs on network connectivity and demonstrate an algorithm that predicts the most effective drug combinations to normalize both the activity patterns and the animal behavior.