Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders

Brain disorders are associated with network dysfunctions that are not addressed by conventional drug screens. Here, the authors use high-throughput functional imaging of brain activity in zebrafish larvae to study the effects of individual drugs on network connectivity and demonstrate an algorithm t...

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Autores principales:	Mostafa Ghannad-Rezaie, Peter M. Eimon, Yuelong Wu, Mehmet Fatih Yanik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc9b629481084e6bb8ce6ed68a64b036
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spelling	oai:doaj.org-article:cc9b629481084e6bb8ce6ed68a64b0362021-12-02T14:38:47ZEngineering brain activity patterns by neuromodulator polytherapy for treatment of disorders10.1038/s41467-019-10541-12041-1723https://doaj.org/article/cc9b629481084e6bb8ce6ed68a64b0362019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10541-1https://doaj.org/toc/2041-1723Brain disorders are associated with network dysfunctions that are not addressed by conventional drug screens. Here, the authors use high-throughput functional imaging of brain activity in zebrafish larvae to study the effects of individual drugs on network connectivity and demonstrate an algorithm that predicts the most effective drug combinations to normalize both the activity patterns and the animal behavior.Mostafa Ghannad-RezaiePeter M. EimonYuelong WuMehmet Fatih YanikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mostafa Ghannad-Rezaie Peter M. Eimon Yuelong Wu Mehmet Fatih Yanik Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders
description	Brain disorders are associated with network dysfunctions that are not addressed by conventional drug screens. Here, the authors use high-throughput functional imaging of brain activity in zebrafish larvae to study the effects of individual drugs on network connectivity and demonstrate an algorithm that predicts the most effective drug combinations to normalize both the activity patterns and the animal behavior.
format	article
author	Mostafa Ghannad-Rezaie Peter M. Eimon Yuelong Wu Mehmet Fatih Yanik
author_facet	Mostafa Ghannad-Rezaie Peter M. Eimon Yuelong Wu Mehmet Fatih Yanik
author_sort	Mostafa Ghannad-Rezaie
title	Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders
title_short	Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders
title_full	Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders
title_fullStr	Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders
title_full_unstemmed	Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders
title_sort	engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cc9b629481084e6bb8ce6ed68a64b036
work_keys_str_mv	AT mostafaghannadrezaie engineeringbrainactivitypatternsbyneuromodulatorpolytherapyfortreatmentofdisorders AT petermeimon engineeringbrainactivitypatternsbyneuromodulatorpolytherapyfortreatmentofdisorders AT yuelongwu engineeringbrainactivitypatternsbyneuromodulatorpolytherapyfortreatmentofdisorders AT mehmetfatihyanik engineeringbrainactivitypatternsbyneuromodulatorpolytherapyfortreatmentofdisorders
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Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders

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