Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition

Soluble vascular endothelial growth factor (VEGF) enhances vascular engraftment of transplanted cells but the efficacy is low. Here, the authors show that VEGF-immobilized microparticles prolong survival of endothelial progenitors in vitro and in vivo by downregulating miR17 and upregulating CDKN1A...

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Autores principales:	Sezin Aday, Janet Zoldan, Marie Besnier, Laura Carreto, Jaimy Saif, Rui Fernandes, Tiago Santos, Liliana Bernardino, Robert Langer, Costanza Emanueli, Lino Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc9c6eafaf1e4d7fa795b816dacd8e45
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spelling	oai:doaj.org-article:cc9c6eafaf1e4d7fa795b816dacd8e452021-12-02T14:42:02ZSynthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition10.1038/s41467-017-00746-72041-1723https://doaj.org/article/cc9c6eafaf1e4d7fa795b816dacd8e452017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00746-7https://doaj.org/toc/2041-1723Soluble vascular endothelial growth factor (VEGF) enhances vascular engraftment of transplanted cells but the efficacy is low. Here, the authors show that VEGF-immobilized microparticles prolong survival of endothelial progenitors in vitro and in vivo by downregulating miR17 and upregulating CDKN1A and ZNF652.Sezin AdayJanet ZoldanMarie BesnierLaura CarretoJaimy SaifRui FernandesTiago SantosLiliana BernardinoRobert LangerCostanza EmanueliLino FerreiraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sezin Aday Janet Zoldan Marie Besnier Laura Carreto Jaimy Saif Rui Fernandes Tiago Santos Liliana Bernardino Robert Langer Costanza Emanueli Lino Ferreira Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
description	Soluble vascular endothelial growth factor (VEGF) enhances vascular engraftment of transplanted cells but the efficacy is low. Here, the authors show that VEGF-immobilized microparticles prolong survival of endothelial progenitors in vitro and in vivo by downregulating miR17 and upregulating CDKN1A and ZNF652.
format	article
author	Sezin Aday Janet Zoldan Marie Besnier Laura Carreto Jaimy Saif Rui Fernandes Tiago Santos Liliana Bernardino Robert Langer Costanza Emanueli Lino Ferreira
author_facet	Sezin Aday Janet Zoldan Marie Besnier Laura Carreto Jaimy Saif Rui Fernandes Tiago Santos Liliana Bernardino Robert Langer Costanza Emanueli Lino Ferreira
author_sort	Sezin Aday
title	Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
title_short	Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
title_full	Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
title_fullStr	Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
title_full_unstemmed	Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
title_sort	synthetic microparticles conjugated with vegf165 improve the survival of endothelial progenitor cells via microrna-17 inhibition
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cc9c6eafaf1e4d7fa795b816dacd8e45
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Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition

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