PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene and display synthetic lethality with nicotinami...

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Autores principales:	Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc9d2729a55c414fbabbdf50c1cccd2e
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spelling	oai:doaj.org-article:cc9d2729a55c414fbabbdf50c1cccd2e2021-12-02T17:01:26ZPPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma10.1038/s41467-019-11732-62041-1723https://doaj.org/article/cc9d2729a55c414fbabbdf50c1cccd2e2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11732-6https://doaj.org/toc/2041-1723Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene and display synthetic lethality with nicotinamide phosphoribosyltransferase inhibitors.Nathan R. FonsRanjini K. SundaramGregory A. BreuerSen PengRyan L. McLeanAravind N. KalathilMark S. SchmidtDiana M. CarvalhoAlan MackayChris JonesÁngel M. CarcabosoJavad NazarianMichael E. BerensCharles BrennerRanjit S. BindraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan R. Fons Ranjini K. Sundaram Gregory A. Breuer Sen Peng Ryan L. McLean Aravind N. Kalathil Mark S. Schmidt Diana M. Carvalho Alan Mackay Chris Jones Ángel M. Carcaboso Javad Nazarian Michael E. Berens Charles Brenner Ranjit S. Bindra PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
description	Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene and display synthetic lethality with nicotinamide phosphoribosyltransferase inhibitors.
format	article
author	Nathan R. Fons Ranjini K. Sundaram Gregory A. Breuer Sen Peng Ryan L. McLean Aravind N. Kalathil Mark S. Schmidt Diana M. Carvalho Alan Mackay Chris Jones Ángel M. Carcaboso Javad Nazarian Michael E. Berens Charles Brenner Ranjit S. Bindra
author_facet	Nathan R. Fons Ranjini K. Sundaram Gregory A. Breuer Sen Peng Ryan L. McLean Aravind N. Kalathil Mark S. Schmidt Diana M. Carvalho Alan Mackay Chris Jones Ángel M. Carcaboso Javad Nazarian Michael E. Berens Charles Brenner Ranjit S. Bindra
author_sort	Nathan R. Fons
title	PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
title_short	PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
title_full	PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
title_fullStr	PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
title_full_unstemmed	PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
title_sort	ppm1d mutations silence naprt gene expression and confer nampt inhibitor sensitivity in glioma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cc9d2729a55c414fbabbdf50c1cccd2e
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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

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