Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

The E46K α-synuclein mutation causes familial Parkinson’s disease. Here, the authors present the cryo-EM structure of N-terminally acetylated E46K α-synuclein fibrils and find that it is distinct from other known α-synuclein fibril structures.

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Autores principales:	Kun Zhao, Yaowang Li, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-dong Su, Dan Li, Xueming Li, Cong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc9dbfd9711d43aea145abb7f8f9e3c5
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spelling	oai:doaj.org-article:cc9dbfd9711d43aea145abb7f8f9e3c52021-12-02T16:52:57ZParkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure10.1038/s41467-020-16386-32041-1723https://doaj.org/article/cc9dbfd9711d43aea145abb7f8f9e3c52020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16386-3https://doaj.org/toc/2041-1723The E46K α-synuclein mutation causes familial Parkinson’s disease. Here, the authors present the cryo-EM structure of N-terminally acetylated E46K α-synuclein fibrils and find that it is distinct from other known α-synuclein fibril structures.Kun ZhaoYaowang LiZhenying LiuHoufang LongChunyu ZhaoFeng LuoYunpeng SunYouqi TaoXiao-dong SuDan LiXueming LiCong LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kun Zhao Yaowang Li Zhenying Liu Houfang Long Chunyu Zhao Feng Luo Yunpeng Sun Youqi Tao Xiao-dong Su Dan Li Xueming Li Cong Liu Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
description	The E46K α-synuclein mutation causes familial Parkinson’s disease. Here, the authors present the cryo-EM structure of N-terminally acetylated E46K α-synuclein fibrils and find that it is distinct from other known α-synuclein fibril structures.
format	article
author	Kun Zhao Yaowang Li Zhenying Liu Houfang Long Chunyu Zhao Feng Luo Yunpeng Sun Youqi Tao Xiao-dong Su Dan Li Xueming Li Cong Liu
author_facet	Kun Zhao Yaowang Li Zhenying Liu Houfang Long Chunyu Zhao Feng Luo Yunpeng Sun Youqi Tao Xiao-dong Su Dan Li Xueming Li Cong Liu
author_sort	Kun Zhao
title	Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
title_short	Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
title_full	Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
title_fullStr	Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
title_full_unstemmed	Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
title_sort	parkinson’s disease associated mutation e46k of α-synuclein triggers the formation of a distinct fibril structure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc9dbfd9711d43aea145abb7f8f9e3c5
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Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

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