Impact of physical activity on the association between lipid profiles and mortality among older people

Abstract High serum lipid levels are independent predictors of mortality risk in the general population. Recent data suggest that this may not apply in the older populations, and even acts in the opposite direction. In consideration of the frail state, minimum amount of physical activity (60–100 min...

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Autores principales:	Shuo-Ming Ou, Yung-Tai Chen, Chia-Jen Shih, Der-Cherng Tarng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc9de34678d84346934b0ba5a1ae567b
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spelling	oai:doaj.org-article:cc9de34678d84346934b0ba5a1ae567b2021-12-02T15:05:57ZImpact of physical activity on the association between lipid profiles and mortality among older people10.1038/s41598-017-07857-72045-2322https://doaj.org/article/cc9de34678d84346934b0ba5a1ae567b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07857-7https://doaj.org/toc/2045-2322Abstract High serum lipid levels are independent predictors of mortality risk in the general population. Recent data suggest that this may not apply in the older populations, and even acts in the opposite direction. In consideration of the frail state, minimum amount of physical activity (60–100 minutes each week) may be more suitable for older individuals but its role in lipid profiles has never been explored. Between 2006 and 2010, we conducted a cohort study of 83,820 participants aged ≥65 years using the Taipei City Elderly Health Examination Database. Participants were classified as inactive, low or high in their level of physical activity. Older individuals with lowest quintile of total cholesterol, non-HDL and HDL were associated with increased risk of all-cause mortality compared to those with other quintile of these lipid profiles. Compared to inactive older individuals, both low (adjusted hazard ratios [aHR] 0.75, 95% confidence interval [CI] 0.70–0.81) and high active older individuals (aHR 0.55, 95% CI 0.51–0.59) were associated with lower risks of mortality. Physical activity, even minimum volume of exercise, in older people has to be encouraged to reduce the increased risk of mortality from low serum lipid levels.Shuo-Ming OuYung-Tai ChenChia-Jen ShihDer-Cherng TarngNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuo-Ming Ou Yung-Tai Chen Chia-Jen Shih Der-Cherng Tarng Impact of physical activity on the association between lipid profiles and mortality among older people
description	Abstract High serum lipid levels are independent predictors of mortality risk in the general population. Recent data suggest that this may not apply in the older populations, and even acts in the opposite direction. In consideration of the frail state, minimum amount of physical activity (60–100 minutes each week) may be more suitable for older individuals but its role in lipid profiles has never been explored. Between 2006 and 2010, we conducted a cohort study of 83,820 participants aged ≥65 years using the Taipei City Elderly Health Examination Database. Participants were classified as inactive, low or high in their level of physical activity. Older individuals with lowest quintile of total cholesterol, non-HDL and HDL were associated with increased risk of all-cause mortality compared to those with other quintile of these lipid profiles. Compared to inactive older individuals, both low (adjusted hazard ratios [aHR] 0.75, 95% confidence interval [CI] 0.70–0.81) and high active older individuals (aHR 0.55, 95% CI 0.51–0.59) were associated with lower risks of mortality. Physical activity, even minimum volume of exercise, in older people has to be encouraged to reduce the increased risk of mortality from low serum lipid levels.
format	article
author	Shuo-Ming Ou Yung-Tai Chen Chia-Jen Shih Der-Cherng Tarng
author_facet	Shuo-Ming Ou Yung-Tai Chen Chia-Jen Shih Der-Cherng Tarng
author_sort	Shuo-Ming Ou
title	Impact of physical activity on the association between lipid profiles and mortality among older people
title_short	Impact of physical activity on the association between lipid profiles and mortality among older people
title_full	Impact of physical activity on the association between lipid profiles and mortality among older people
title_fullStr	Impact of physical activity on the association between lipid profiles and mortality among older people
title_full_unstemmed	Impact of physical activity on the association between lipid profiles and mortality among older people
title_sort	impact of physical activity on the association between lipid profiles and mortality among older people
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cc9de34678d84346934b0ba5a1ae567b
work_keys_str_mv	AT shuomingou impactofphysicalactivityontheassociationbetweenlipidprofilesandmortalityamongolderpeople AT yungtaichen impactofphysicalactivityontheassociationbetweenlipidprofilesandmortalityamongolderpeople AT chiajenshih impactofphysicalactivityontheassociationbetweenlipidprofilesandmortalityamongolderpeople AT dercherngtarng impactofphysicalactivityontheassociationbetweenlipidprofilesandmortalityamongolderpeople
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Impact of physical activity on the association between lipid profiles and mortality among older people

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