Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.

Previous studies have demonstrated the involvement of complement (C) in induction of efficient CTL responses against different viral infections, but the exact role of complement in this process has not been determined. We now show that C opsonization of retroviral particles enhances the ability of d...

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Autores principales:	Zoltán Bánki, Wilfried Posch, Asim Ejaz, Verena Oberhauser, Suzanne Willey, Christoph Gassner, Heribert Stoiber, Ulf Dittmer, Manfred P Dierich, Kim J Hasenkrug, Doris Wilflingseder
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cc9f407cf1f7471bba414ce1478bfaa0
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spelling	oai:doaj.org-article:cc9f407cf1f7471bba414ce1478bfaa02021-12-02T20:00:43ZComplement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.1553-73661553-737410.1371/journal.ppat.1000891https://doaj.org/article/cc9f407cf1f7471bba414ce1478bfaa02010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20442876/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Previous studies have demonstrated the involvement of complement (C) in induction of efficient CTL responses against different viral infections, but the exact role of complement in this process has not been determined. We now show that C opsonization of retroviral particles enhances the ability of dendritic cells (DCs) to induce CTL responses both in vitro and in vivo. DCs exposed to C-opsonized HIV in vitro were able to stimulate CTLs to elicit antiviral activity significantly better than non-opsonized HIV. Furthermore, experiments using the Friend virus (FV) mouse model illustrated that the enhancing role of complement on DC-mediated CTL induction also occurred in vivo. Our results indicate that complement serves as natural adjuvant for DC-induced expansion and differentiation of specific CTLs against retroviruses.Zoltán BánkiWilfried PoschAsim EjazVerena OberhauserSuzanne WilleyChristoph GassnerHeribert StoiberUlf DittmerManfred P DierichKim J HasenkrugDoris WilflingsederPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 4, p e1000891 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Zoltán Bánki Wilfried Posch Asim Ejaz Verena Oberhauser Suzanne Willey Christoph Gassner Heribert Stoiber Ulf Dittmer Manfred P Dierich Kim J Hasenkrug Doris Wilflingseder Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.
description	Previous studies have demonstrated the involvement of complement (C) in induction of efficient CTL responses against different viral infections, but the exact role of complement in this process has not been determined. We now show that C opsonization of retroviral particles enhances the ability of dendritic cells (DCs) to induce CTL responses both in vitro and in vivo. DCs exposed to C-opsonized HIV in vitro were able to stimulate CTLs to elicit antiviral activity significantly better than non-opsonized HIV. Furthermore, experiments using the Friend virus (FV) mouse model illustrated that the enhancing role of complement on DC-mediated CTL induction also occurred in vivo. Our results indicate that complement serves as natural adjuvant for DC-induced expansion and differentiation of specific CTLs against retroviruses.
format	article
author	Zoltán Bánki Wilfried Posch Asim Ejaz Verena Oberhauser Suzanne Willey Christoph Gassner Heribert Stoiber Ulf Dittmer Manfred P Dierich Kim J Hasenkrug Doris Wilflingseder
author_facet	Zoltán Bánki Wilfried Posch Asim Ejaz Verena Oberhauser Suzanne Willey Christoph Gassner Heribert Stoiber Ulf Dittmer Manfred P Dierich Kim J Hasenkrug Doris Wilflingseder
author_sort	Zoltán Bánki
title	Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.
title_short	Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.
title_full	Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.
title_fullStr	Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.
title_full_unstemmed	Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.
title_sort	complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific ctls.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/cc9f407cf1f7471bba414ce1478bfaa0
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Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.

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