IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN

This review concerns studies of compensatory mechanisms in the antioxidant defense, intensification of lipid peroxidation products, assays of local and systemic cytokine profile in COPD patients, thus allowing to determine the molecular phenotypes of systemic inflammatory response. The first of thes...

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Autores principales:	E. P. Kalinina, E. G. Lobanova, M. V. Antonyuk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic obstructive pulmonary disease phenotypes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cc9f85331b5f4fbe9b2313e3eda5275c
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spelling	oai:doaj.org-article:cc9f85331b5f4fbe9b2313e3eda5275c2021-11-18T08:03:44ZIMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN1563-06252313-741X10.15789/1563-0625-2014-4-375-380https://doaj.org/article/cc9f85331b5f4fbe9b2313e3eda5275c2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/704https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThis review concerns studies of compensatory mechanisms in the antioxidant defense, intensification of lipid peroxidation products, assays of local and systemic cytokine profile in COPD patients, thus allowing to determine the molecular phenotypes of systemic inflammatory response. The first of these phenotypes is characterized by certain biomarker combination, i.e., balanced lipid peroxidation and antioxidant defense system, many-fold increase in tissue and systemic concentrations of TFG-β1, high TNFα level. This phenotype is characterized by a moderate immunosuppression, balanced inflammation in respiratory tract. A set of biomarkers typical to the second phenotype may be characterized by activation of free radical lipid oxidation, high levels of of TNFα, bFGF and TGF-β1 secretion, increased sTNFα RI (p55), along with decreased synthesis of a chemoattractant IL-8 cytokine. This phenotype is characterized by an immunosuppressive imbalance causing inflammation in respiratory tract. The third phenotype is associated with the following biomarkers: inactivation of peroxidation processes, high-level secretion of TNFα, bFGF, and sTNFα RI (p55) and decreased TGF-β1 and IL-8 synthesis, thus resulting into imbalanced immunodeficient inflammation in respiratory tract.E. P. KalininaE. G. LobanovaM. V. AntonyukSPb RAACIarticlechronic obstructive pulmonary diseasephenotypesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 4, Pp 375-380 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic obstructive pulmonary disease phenotypes Immunologic diseases. Allergy RC581-607
spellingShingle	chronic obstructive pulmonary disease phenotypes Immunologic diseases. Allergy RC581-607 E. P. Kalinina E. G. Lobanova M. V. Antonyuk IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN
description	This review concerns studies of compensatory mechanisms in the antioxidant defense, intensification of lipid peroxidation products, assays of local and systemic cytokine profile in COPD patients, thus allowing to determine the molecular phenotypes of systemic inflammatory response. The first of these phenotypes is characterized by certain biomarker combination, i.e., balanced lipid peroxidation and antioxidant defense system, many-fold increase in tissue and systemic concentrations of TFG-β1, high TNFα level. This phenotype is characterized by a moderate immunosuppression, balanced inflammation in respiratory tract. A set of biomarkers typical to the second phenotype may be characterized by activation of free radical lipid oxidation, high levels of of TNFα, bFGF and TGF-β1 secretion, increased sTNFα RI (p55), along with decreased synthesis of a chemoattractant IL-8 cytokine. This phenotype is characterized by an immunosuppressive imbalance causing inflammation in respiratory tract. The third phenotype is associated with the following biomarkers: inactivation of peroxidation processes, high-level secretion of TNFα, bFGF, and sTNFα RI (p55) and decreased TGF-β1 and IL-8 synthesis, thus resulting into imbalanced immunodeficient inflammation in respiratory tract.
format	article
author	E. P. Kalinina E. G. Lobanova M. V. Antonyuk
author_facet	E. P. Kalinina E. G. Lobanova M. V. Antonyuk
author_sort	E. P. Kalinina
title	IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN
title_short	IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN
title_full	IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN
title_fullStr	IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN
title_full_unstemmed	IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN
title_sort	immune and metabolic phenotypes of chronic obstructive pulmonary disease in men
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/cc9f85331b5f4fbe9b2313e3eda5275c
work_keys_str_mv	AT epkalinina immuneandmetabolicphenotypesofchronicobstructivepulmonarydiseaseinmen AT eglobanova immuneandmetabolicphenotypesofchronicobstructivepulmonarydiseaseinmen AT mvantonyuk immuneandmetabolicphenotypesofchronicobstructivepulmonarydiseaseinmen
_version_	1718422447661776896

IMMUNE AND METABOLIC PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MEN

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