Adenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cells

Abstract Extracellular adenosine suppresses T cell immunity in the tumor microenvironment and in vitro treatment of memory T cells with adenosine can suppress antigen-mediated memory T cell expansion. We describe utilizing the recall antigen assay platform to screen small molecule drug off-target ef...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Eden Kleiman, Gloria Sierra, Binchen Mao, Dennie Magcase, Marybeth V. George, Pirouz M. Daftarian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/cca0be82758d4e3d8e345de69c239545
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!