Adenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cells
Abstract Extracellular adenosine suppresses T cell immunity in the tumor microenvironment and in vitro treatment of memory T cells with adenosine can suppress antigen-mediated memory T cell expansion. We describe utilizing the recall antigen assay platform to screen small molecule drug off-target ef...
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Autores principales: | Eden Kleiman, Gloria Sierra, Binchen Mao, Dennie Magcase, Marybeth V. George, Pirouz M. Daftarian |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/cca0be82758d4e3d8e345de69c239545 |
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