Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of...

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Autores principales:	Laura Pirovano, Simone Culurgioni, Manuel Carminati, Andrea Alfieri, Silvia Monzani, Valentina Cecatiello, Chiara Gaddoni, Francesca Rizzelli, James Foadi, Sebastiano Pasqualato, Marina Mapelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cca2029813694381ba0884810c0da218
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spelling	oai:doaj.org-article:cca2029813694381ba0884810c0da2182021-12-02T15:35:31ZHexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions10.1038/s41467-019-09999-w2041-1723https://doaj.org/article/cca2029813694381ba0884810c0da2182019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09999-whttps://doaj.org/toc/2041-1723LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of active cortical dynein/dynactin motors.Laura PirovanoSimone CulurgioniManuel CarminatiAndrea AlfieriSilvia MonzaniValentina CecatielloChiara GaddoniFrancesca RizzelliJames FoadiSebastiano PasqualatoMarina MapelliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Pirovano Simone Culurgioni Manuel Carminati Andrea Alfieri Silvia Monzani Valentina Cecatiello Chiara Gaddoni Francesca Rizzelli James Foadi Sebastiano Pasqualato Marina Mapelli Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
description	LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of active cortical dynein/dynactin motors.
format	article
author	Laura Pirovano Simone Culurgioni Manuel Carminati Andrea Alfieri Silvia Monzani Valentina Cecatiello Chiara Gaddoni Francesca Rizzelli James Foadi Sebastiano Pasqualato Marina Mapelli
author_facet	Laura Pirovano Simone Culurgioni Manuel Carminati Andrea Alfieri Silvia Monzani Valentina Cecatiello Chiara Gaddoni Francesca Rizzelli James Foadi Sebastiano Pasqualato Marina Mapelli
author_sort	Laura Pirovano
title	Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
title_short	Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
title_full	Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
title_fullStr	Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
title_full_unstemmed	Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
title_sort	hexameric numa:lgn structures promote multivalent interactions required for planar epithelial divisions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cca2029813694381ba0884810c0da218
work_keys_str_mv	AT laurapirovano hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT simoneculurgioni hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT manuelcarminati hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT andreaalfieri hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT silviamonzani hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT valentinacecatiello hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT chiaragaddoni hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT francescarizzelli hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT jamesfoadi hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT sebastianopasqualato hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions AT marinamapelli hexamericnumalgnstructurespromotemultivalentinteractionsrequiredforplanarepithelialdivisions
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Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

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